Related LncRNAs |
ID |
lncRNA Name |
Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
EL0038 |
AF118081 |
lung cancer |
qPCR, knockdown etc. |
lung cancer tissue, cell lines (16HBE) |
up-regulated |
regulation |
LncRNA AF118081 was identified as the most significantly overexpressed lncRNA in 16HBE-T cells, lung cancer cells, and patient samples. Cell proliferation, colony formation, apoptosis, migration, and invasion were assayed in 16HBE-T cells following the knockdown of lncRNA AF118081 with small interfering RNA. AF118081 knockdown inhibited cell growth and tumor invasion. An in vivo (nude mouse) model was then used to assay tumor growth, and the downregulation of AF118081 clearly suppressed tumor growth, consistent with the results of the in vitro assays. |
25050996 |
Lnc2Cancer
|
EL0040 |
AFAP1-AS1 |
lung cancer |
RNA-seq, qPCR, Western blot etc. |
cell line (A549 ) |
up-regulated |
interaction |
AFAP1-AS1 was the most significantly upregulated in lung cancer and associated with poor prognosis. AFAP1-AS1 knockdown significantly inhibited the cell invasive and migration capability in lung cancer cells. AFAP1-AS1 knockdown also increased the expression of its antisense protein coding gene, actin filament associated protein 1 (AFAP1), and affected the expression levels of several small GTPase family members and molecules in the actin cytokeratin signaling pathway, which suggested that AFAP1-AS1 promoted cancer cell metastasis via regulation of actin filament integrity. |
26245991 |
Lnc2Cancer
|
EL0227 |
BANCR |
lung cancer |
qPCR, Western blot etc. |
lung cancer tissue, cell lines (NCI-H1688, NCI-H446) |
down-regulated |
expression |
The results showed that BANCR levels were downregulated in LC cells. When BANCR expression was improved by tranfetcion with pcDNA-BANCR vetcor, tumor growth was suppressed.Vise versa, when BANCR was knockdown by si-BANCR, cell proliferation and migration of LC were remarkably promoted. We further found that MAPK pathways were involved in the BANCR-mediated cell proliferation and migration of LC. |
25661343 |
Lnc2Cancer
|
EL0237 |
BCYRN1 |
lung cancer |
ISH, Northern hybridization etc. |
lung cancer tissue |
up-regulated |
expression |
BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. |
9422992 |
LncRNADisease Lnc2Cancer
|
EL0556 |
H19 |
lung cancer |
N/A |
N/A |
N/A |
regulation |
Control of imprinting. Containing miRNA miR-675. |
22996375 |
LncRNADisease
|
EL0556 |
H19 |
lung cancer |
N/A |
N/A |
N/A |
regulation |
Control of imprinting breast, cervix, oesophagus prostate, endometrial, colon |
24499465 |
LncRNADisease
|
EL0556 |
H19 |
lung cancer |
qPCR etc. |
cell lines (MCF10A, RPMI 1640, DMEM H21 etc.) |
up-regulated |
expression |
Down-regulation of H19 significantly decreases breast and lung cancer cell clonogenicity and anchorage-independent growth. In addition, c-Myc and H19 expression shows strong association in primary breast and lung carcinomas. |
16707459 |
LncRNADisease Lnc2Cancer
|
EL0556 |
H19 |
lung cancer |
qPCR etc. |
cell lines (A549) |
down-regulated |
N/A |
Comparing with respective normal cell line, H19 was found highly expressed in stomach cancer cell lines (AGS, MGC-803 and SGC-7901) and hepatocellular carcinoma cell lines (SMMC-7721 and HepG2), while lowly expressed in lung cancer cell line (A549) and prostate cancer cell lines (Du-145 and PC-3). |
24063685 |
Lnc2Cancer
|
EL0578 |
HOTAIR |
lung cancer |
N/A |
N/A |
N/A |
expression |
Upregulation of HOTAIR is associated with metastasis of gastric cancer, lung cancer, and esophageal squamous cell carcinoma? |
24757675 |
LncRNADisease
|
EL0578 |
HOTAIR |
lung cancer |
qPCR etc. |
lung cancer tissue cell lines (A549, mK-ras-LE etc.) |
up-regulated |
N/A |
In the current study, we demonstrate that the tumor-promoting lincRNA HOTAIR is induced by Col-1 and its expression inversely correlates with acinar morphogenesis, a differentiation feature of lung epithelial cells in rBM 3-D culture. These in vitro findings suggest that the elevated HOTAIR expression in tumor tissues results from cancer cells' response to Col-1 that is aberrantly enriched in the tumor microenvironment. Our findings indicate that tumor-promoting Col-1 up-regulates the expression of HOTAIR in NSCLC cells. These initial results warrant further investigation of HOTAIR and other lincRNA genes in lung tumorigenesis. |
23668363 |
Lnc2Cancer
|
EL0578 |
HOTAIR |
lung cancer |
qPCR, knockdown etc. |
lung cancer tissue |
up-regulated |
N/A |
Among the tested lncRNAs, HOTAIR and NEAT1 were most highly expressed in lymph node metastasis. However, only HOTAIR was subsequently found to be involved in lung cancer cell motility and invasion, as assessed by in vitro migration and invasion assay. |
25010625 |
Lnc2Cancer
|
EL0582 |
HOTTIP |
lung cancer |
N/A |
lung cancer cell line A549 and NCI-H446; tissue of lung cancer |
up-regulated |
expression |
Initially, we found that expression of HOTTIP was significantly elevated in 20 cases of lung cancer.Tumor growth in vivo was also suppressed after depletion of HOTTIP in a mouse model of lung cancer. Moreover, depletion of HOTTIP caused cell cycle arrest in G0/G1 phase and induced significant cell apoptosis. |
26265284 |
|
EL0640 |
LCAL1 |
lung cancer |
RNA-Seq, qPCR, knockdown etc. |
lung cancer tissue |
up-regulated |
expression |
Stable overexpression of LCAL1, using two different clones, in the control cell line BEAS-2B showed a significant increase in cellular proliferation starting on day 2 and continuing until the end of the experiment at day 6 with a 38% and 43% growth increase, respetcively. Overexpression of LCAL1 in normal BEAS-2B cells is proof of principle that this lncRNA is sufficient to affetc cellular growth independently of other common cancer mutations, thus highlighting the importance of LCAL1 in lung cancer biology. |
25116943 |
Lnc2Cancer
|
EL0655 |
LINC00313 |
lung cancer |
microarray, qRT-PCR |
tissues from 181 early-stage lung cancer patients |
up-regulated |
expression |
Notably, a novel lncRNA, LINC00313, was highly expressed in both T2- and N1-stage lung cancers. On the other hand, LINC00313 was also upregulated in lung cancer and metastasized lung cancer tissues, compared with adjacent lung tissues and primary lung cancer tissues. LINC00313 could be a biomarker for lung cancer. |
26178480 |
|
EL0682 |
LINC01024 |
lung cancer |
qPCR, Western blot, knockdown etc. |
cell lines (H1299) |
up-regulated |
interaction |
We employed qPCR to analyze MA-linc1 levels in four cell lines: U2OS and H1299 cells, as well as the human embryonic lung fibroblasts, WI38, and another human osteosarcoma cell line, SAOS-2, each expressing the conditionally active E2F1. This analysis demonstrated that activation of the ectopic E2F1 resulted in a significant increase in MA-linc1 RNA levels in all four cell lines. |
26337085 |
Lnc2Cancer
|
EL0696 |
LINC01433 |
lung cancer |
microarray, qPCR, Western blot, knockdown etc. |
cell line (16HBE) |
up-regulated |
N/A |
LOC728228 was upregulated relative to its expression in control untransformed16HBE (16HBE-N) cells. |
25820656 |
LncRNADisease Lnc2Cancer
|
EL0715 |
linc-CBR1-2 |
lung cancer |
microarray, qPCR, knockdown etc. |
lung cancer tissue |
up-regulated |
N/A |
To validate our findings, we selected one lincRNA and three mRNAs for validation. Of these, linc-CBR1-2, and two mRNAs, RAB25 and HMBG3 were up-regulated in AIS compared to nomal tisssu. |
24735754 |
Lnc2Cancer
|
EL0764 |
lnc-bc060912 |
lung cancer |
qPCR, Northern blot, knockdown, RIP etc. |
cell lines (H1299, A549, 293T) |
up-regulated |
interaction |
Here we have identified a lncRNA termed Lnc-bc060912 whose expression is increased in human lung and other tumors. Lnc-bc060912 suppressed cell apoptosis. Lnc-bc060912 via PARP1 and NPM1, affects cell apoptosis and may play important roles in tumorigenesis and cancer progression. |
25848691 |
Lnc2Cancer
|
EL0800 |
lncRNA-DQ786227 |
lung cancer |
microarray, qPCR, in vitro knockdown etc. |
cell lines (A549, QG56 etc.) |
up-regulated |
N/A |
Expression of lncRNA-DQ786227 in both lung cancer cells differed from that in BEAS-2B cells. Expression of lncRNA-DQ786227 was significantly higher in the A549 and QG56 cells compared with the BEAS-2B cells.Our findings revealed that lncRNA-DQ786227 might act as an oncogene. Our study provides a new insight regarding the oncogenic properties of lncRNA in B[a]P-induced cell transformation. |
24084393 |
Lnc2Cancer
|
EL0836 |
LSINCT1 |
lung cancer |
qPCR, Northern blot etc. |
cell lines (T47D, BT474, NCF10A etc.) |
up-regulated |
N/A |
Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. |
20214974 |
Lnc2Cancer
|
EL0837 |
LSINCT10 |
lung cancer |
qPCR, Northern blot etc. |
cell lines (T47D, BT474, NCF10A etc.) |
up-regulated |
N/A |
Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. |
20214974 |
Lnc2Cancer
|
EL0838 |
LSINCT11 |
lung cancer |
qPCR, Northern blot etc. |
cell lines (T47D, BT474, NCF10A etc.) |
up-regulated |
N/A |
Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. |
20214974 |
Lnc2Cancer
|
EL0839 |
LSINCT12 |
lung cancer |
qPCR, Northern blot etc. |
cell lines (T47D, BT474, NCF10A etc.) |
up-regulated |
N/A |
Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. |
20214974 |
Lnc2Cancer
|
EL0840 |
LSINCT2 |
lung cancer |
qPCR, Northern blot etc. |
cell lines (T47D, BT474, NCF10A etc.) |
up-regulated |
N/A |
Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. |
20214974 |
Lnc2Cancer
|
EL0841 |
LSINCT3 |
lung cancer |
qPCR, Northern blot etc. |
cell lines (T47D, BT474, NCF10A etc.) |
up-regulated |
N/A |
Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. |
20214974 |
Lnc2Cancer
|
EL0842 |
LSINCT4 |
lung cancer |
qPCR, Northern blot etc. |
cell lines (T47D, BT474, NCF10A etc.) |
up-regulated |
N/A |
Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. |
20214974 |
Lnc2Cancer
|
EL0843 |
LSINCT5 |
lung cancer |
qPCR, Northern blot etc. |
cell lines (T47D, BT474, NCF10A etc.) |
up-regulated |
N/A |
Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. |
20214974 |
Lnc2Cancer
|
EL0844 |
LSINCT6 |
lung cancer |
qPCR, Northern blot etc. |
cell lines (T47D, BT474, NCF10A etc.) |
up-regulated |
N/A |
Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. |
20214974 |
Lnc2Cancer
|
EL0845 |
LSINCT7 |
lung cancer |
qPCR, Northern blot etc. |
cell lines (T47D, BT474, NCF10A etc.) |
up-regulated |
N/A |
Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. |
20214974 |
Lnc2Cancer
|
EL0846 |
LSINCT8 |
lung cancer |
qPCR, Northern blot etc. |
cell lines (T47D, BT474, NCF10A etc.) |
up-regulated |
N/A |
Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. |
20214974 |
Lnc2Cancer
|
EL0847 |
LSINCT9 |
lung cancer |
qPCR, Northern blot etc. |
cell lines (T47D, BT474, NCF10A etc.) |
up-regulated |
N/A |
Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. |
20214974 |
Lnc2Cancer
|
EL0849 |
LUCAT1 |
lung cancer |
qPCR, Western bolt, RIP etc. |
cell lines (A549, CL1-0, CL1-5, H1975, HCC-827, NCI-H292 etc.) |
up-regulated |
N/A |
We found that XLOC_004924 was elevated in the airway epithelia of cigarette smokers versus nonsmokers in both of these datasets. In the first dataset, five nonsmokers were compared with six smokers. In the second study, the smokers' epithelia demonstrated a 3.9-fold increase in XLOC_004924, compared with nonsmokers. Functionally,siRNA knockdown of SCAL1 in HBE1 cells shows significant potentiation of cytotoxicity induced by CSE in vitro. Altogether, these results identify a novel and intriguing new non-coding RNA that may act downstream of NRF2 to regulate gene expression and mediate oxidative stress protection in airway epithelial cells. |
23672216 |
Lnc2Cancer
|
EL0853 |
MALAT1 |
lung cancer |
knockdown |
human bronchial epithelial (HBE) cells |
up-regulated |
interaction |
Cigarette smoke extract (CSE) caused decreases of miR-217 levels and increases in lncRNA MALAT1 levels. The CSE-induced increase of MALAT1 expression was blocked by an miR-217 mimic, indicating that miR-217 negatively regulates MALAT1 expression. |
26415832 |
|
EL0853 |
MALAT1 |
lung cancer |
N/A |
N/A |
N/A |
regulation |
Sequesters SR splicing factors to regulate alternative splicing. |
22996375 |
LncRNADisease
|
EL0853 |
MALAT1 |
lung cancer |
N/A |
N/A |
N/A |
regulation |
invasion & metastasis pancreas, colon, prostate liver, cervix, neuroblastoma osteosarcoma |
24499465 |
LncRNADisease
|
EL0853 |
MALAT1 |
lung cancer |
N/A |
N/A |
N/A |
expression |
MALAT1, also known as NEAT2 (nuclear-enriched abundant transcript 2), was initially discovered as a predictive biomarker for metastasis development in lung cancer. |
24667321 |
LncRNADisease
|
EL0853 |
MALAT1 |
lung cancer |
N/A |
N/A |
N/A |
expression |
Overexpressed MALAT1 was found in many solid tumors such as lung cancer, cervical cancer, and HCC. |
24757675 |
LncRNADisease
|
EL0853 |
MALAT1 |
lung cancer |
qPCR etc. |
cell lines (A549, A549 MALAT1 KO, EBC-1 etc.) |
up-regulated |
regulation |
The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. |
23243023 |
LncRNADisease Lnc2Cancer
|
EL0853 |
MALAT1 |
lung cancer |
qPCR etc. |
blood |
down-regulated |
expression |
The expression of MALAT1 in the whole blood of lung cancer patients with metastasis was stronger compared to non-metastasis, which showed that MALAT1 promotes the tumor metastasis and additionally, the whole blood with lymph node metastasis represented a lower expression of MALAT1 compared to bone or brain metastasis. |
26137228 |
Lnc2Cancer
|
EL0853 |
MALAT1 |
lung cancer |
qPCR, Northern blot, etc. |
cell lines (H1299, H1975 etc.) |
differential expression |
N/A |
We first examined the decay of MALAT-1 in various cancer cells (H1299, H1975, A549, HT1080, and HeLa TO cells) by DRB chase experiments using 7SK RNA as a control. Half-lives of MALAT-1 in H1299, H1975, A549, HT1080, and HeLa TO cells were > 12, 12, 12, 12, and 9 h, respectively. MALAT-1 stabilities varied in various cancer cells. |
22491206 |
Lnc2Cancer
|
EL0861 |
MEG3 |
lung cancer |
qPCR, ISH etc. |
lung cancer tissue |
down-regulated |
expression |
MEG3 expression is lost. |
14602737 |
LncRNADisease Lnc2Cancer
|
EL0872 |
MINA |
lung cancer |
N/A |
N/A |
N/A |
regulation |
Dysfunction of MDIG was found in several types of solid cancers including gastric carcinoma, esophageal squamous cell carcinoma, and lung cancer. Overexpression of MDIG was observed in hepatocellular carcinoma.? |
24757675 |
LncRNADisease
|
EL0881 |
MIR4435-2HG |
lung cancer |
microarray, qRT-PCR |
lung cancer tissues and A549 cell lines |
up-regulated |
expression |
We observed a significant reduction in cell viability in lung cancer cells and a slow growth in the tumorigenesis following AK001796 knockdown. We also found that AK001796 knockdown caused a cell-cycle arrest, with significant increases in the percentage of cells in G0/G1 in lung cancer cells. Reduced lncRNA AK001796 level potentially impaired the inhibitory effect of resveratrol on cell proliferation. |
25888808 |
|
EL0973 |
NEAT1 |
lung cancer |
qRT-PCR |
lung carcinoma cell lines |
N/A |
expression |
Our data indicate that miR-449a may function as a suppressor of lung cancer, and affects the expression of NEAT1 in lung cancer cells. |
25818739 |
|
EL1011 |
NRG1 |
lung cancer |
qPCR etc. |
lung cancer tissue |
up-regulated |
N/A |
High expression was observed in cancer tissues, which was consistent with our previous study that NRG1 was highly expressed in lung cancer induced by nickel. NRG1 was located on chromosome 2q12, within intron2 of ADAMTS6, a disintegrin and metalloproteinase with thrombospondin motifs. And, NRG1 had a high level of homology (76 %) to rat LINE1 sequence RL1.3 (long interspersed middle repetitive DNA) |
22665269 |
Lnc2Cancer
|
EL1114 |
RGMB-AS1 |
lung cancer |
In vivo experiments |
lung adenocarcinoma cells |
up-regulated |
N/A |
lncRNA RGMB-AS1 downregulation significantly suppressed the growth of lung adenocarcinoma |
26950071 |
|
EL1349 |
TP53COR1 |
lung cancer |
N/A |
N/A |
N/A |
expression |
lincRNAp21 is required for the global repression of genes that interfere with p53 function regulating cellular apoptosis. lincRNAp21 can mediate gene repression by physically interacting with the protein hnRNP-K, allowing its localization to promoters of genes to be repressed in a p53-dependent manner, and its overexpression in a lung cancer cell line sensitizes the cells to DNA |
22535282 |
LncRNADisease
|
EL1349 |
TP53COR1 |
lung cancer |
qPCR etc. |
cell lines (wt MEFs, NIH/3T3 MEFs etc.) |
down-regulated |
expression |
Gas5 has also been linked with breast cancer because Gas5 transcript levels are significantly reduced compared to unaffected normal breast epithelia. |
20673990 |
LncRNADisease Lnc2Cancer
|
EL1416 |
uc001lsz |
lung cancer |
qPCR etc. |
cell lines (A549) |
down-regulated |
N/A |
We found that comparing with respective normal cell line, uc001lsz was lowly expressed in gastric cancer (AGS, MGC-803 and SGC-7901), lung cancer (A549) and liver cancer (SMMC-7721 and HepG2) cell lines, while only highly expressed in prostate cancer (Du-145 and PC-3) cell lines. |
24063685 |
Lnc2Cancer
|
EL1431 |
UCA1 |
lung cancer |
qPCR etc. |
NSCLC tissue |
up-regulated |
expression |
The results showed that the expression of UCA1 in NSCLC tissues was obviously higher than that observed in pair-matched adjacent nontumourous tissues, (P < 0.001). In conclusion, the current results indicated that Plasma UCA1 could serve as a potential biomarker for diagnosis of NSCLC. UCA1 as a biomarker in clinical application might significantly improve the efficacy of human NSCLC screening. |
26380024 |
Lnc2Cancer
|
|