EL1047 |
PARTICL |
low-dose irradiation |
In situ hybridization, surface plasmon resonance, Bromouridine tracing |
samples from radiotherapy-treated patients |
up-regulated |
expression |
Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICLE (gene PARTICLE, promoter of MAT2A-antisense radiation-induced circulating lncRNA). The interplay of PARTICLE with MAT2A implicates this lncRNA in intercellular communication and as a recruitment platform for gene-silencing machineries through triplex formation in response to irradiation. |
25900080 |
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