Related LncRNAs
ID lncRNA Name Disease Method Sample Expression pattern Dysfunction type Description PMID Source
EL0526 GAS5 liver fibrosis overexpression mouse, rat, and human fibrotic liver samples, activated hepatic stellate cell (HSC) down-regulated interaction GAS5 increased the level of p27 protein by functioning as a competing endogenous RNA for miR-222, thereby inhibiting the activation and proliferation of HSCs. Overexpression of GAS5 suppressed the activation of primary HSCs in vitro and alleviated the accumulation of collagen in fibrotic liver tissues in vivo. GAS5 was identified as a target of microRNA-222 (miR-222) and showed that miR-222 could inhibit the expression of GAS5. GAS5 could also repress miR-222 expression. 26446789