EL0526 |
GAS5 |
liver fibrosis |
overexpression |
mouse, rat, and human fibrotic liver samples, activated hepatic stellate cell (HSC) |
down-regulated |
interaction |
GAS5 increased the level of p27 protein by functioning as a competing endogenous RNA for miR-222, thereby inhibiting the activation and proliferation of HSCs. Overexpression of GAS5 suppressed the activation of primary HSCs in vitro and alleviated the accumulation of collagen in fibrotic liver tissues in vivo. GAS5 was identified as a target of microRNA-222 (miR-222) and showed that miR-222 could inhibit the expression of GAS5. GAS5 could also repress miR-222 expression. |
26446789 |
|