Related LncRNAs | |||||||||
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ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
EL0557 | HA117 | hirschsprung disease | N/A | N/A | N/A | N/A | HA117 expression in stenotic segment was higher compared to proximal anastomosis and dilated segment (p < 0.05); HA117 may be a factor exerting an anti-differentiation or anti-maturation role in the genesis of HSCR. | 25120773 | LncRNADisease |
EL0582 | HOTTIP | hirschsprung disease | qRT-PCR, Small RNA interference | colon tissues rom 79 patients with Hirschsprung disease (HSCR) | down-regulated | expression | LncRNA HOTTIP and HOXA13 were significantly down-regulated in HSCR compared to the controls. Meanwhile, the declined extent of their expression levels makes sense between two main phenotype of HSCR. Our study demonstrates that aberrant reduction of HOTTIP and HOXA13, which have a bidirectional regulatory loop, may play an important role in the pathogenesis of HSCR. | 26043692 | |
EL0818 | LINC01844 | hirschsprung disease | qRT-PCR to detect the relative expression of LOC101926975 in 80 pairs of HSCR bowel tissues and matched normal bowel tissues | HSCR bowel tissues and matched normal bowel tissues | down-regulated | N/A | Dysregulation of LOC101926975 suppressed cell proliferation and induced G0/G1 arrest without impact on cell apoptosis or migration | 27076786 | |