| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0013 | AA174084 | gastric cancer | qPCR, RIP etc. | gastric cancer tissue | down-regulated | N/A | Expression levels of AA174084 were down-regulated significantly in 95 of 134 GC tissues (71%) compared with the levels in paired, adjacent, normal tissues. AA174084 levels had significant, negative correlations with age, Borrmann type, and perineural invasion. Plasma AA174084 levels in patients with GC dropped markedly on day 15 after surgery compared with preoperative levels and were associated with invasion and lymphatic metastasis. AA174084 levels in gastric juice from patients with GC were significantly higher than the levels in normal mucosa or in patients with minimal gastritis, gastric ulcers, and atrophic gastritis. The area under ROC was up to 0.848. | 24986041 | Lnc2Cancer |
| EL0019 | ABHD11-AS1 | gastric cancer | qPCR etc. | gastric cancer tissue | up-regulated | N/A | Results show that compared with adjacent nontumor tissues the expression level of ABHD11-AS1 in gastric cancer tissues was significantly increased. | 24984296 | Lnc2Cancer |
| EL0019 | ABHD11-AS1 | gastric cancer | qPCR etc. | gastric cancer tissue, gastric juice | up-regulated | expression | The results showed that ABHD11-AS1 levels in gastric cancer tissues were significantly higher than those in other tissues. Its levels in gastric juice from gastric cancer patients were not only significantly higher than those from cases of normal mucosa or minimal gastritis, atrophic gastritis, and gastric ulcers but also associated with gender, tumor size, tumor stage, Lauren type, and blood carcinoembryonic antigen (CEA) levels. | 26280398 | Lnc2Cancer |
| EL0029 | AC104699.1 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | up-regulated | expression | The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. | 26045391 | Lnc2Cancer |
| EL0042 | AI364715 | gastric cancer | qPCR etc. | gastric cancer tissue | down-regulated | expression | The expression level of AI364715 in gastric cancer tissues was downregulated. Meanwhile, its expression level was closely associated with tumor size and differentiation. | 25971582 | Lnc2Cancer |
| EL0052 | AK057054 | gastric cancer | microarray, qPCR etc. | primary gastric adenocarcinoma tissue | down-regulated | N/A | For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). | 24819045 | Lnc2Cancer |
| EL0066 | AKR7L | gastric cancer | microarray, qPCR, knockdown etc. | gastric cancer tissue | down-regulated | N/A | TUSC7 was downregulated in GC samples and was an independent prognostic indicator of disease-free survival (DFS) and disease-specific survival (DSS) in GC patients; TUSC7 was a direct transcriptional target of p53 via interaction of p53 with the putative p53-response element in the upstream region of TUSC7 | 25765901 | LncRNADisease Lnc2Cancer |
| EL0078 | AP001439.1 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | down-regulated | expression | The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. | 26045391 | Lnc2Cancer |
| EL0227 | BANCR | gastric cancer | qPCR etc. | gastric cancer tissue | up-regulated | interaction | In our results, the expression of BANCR was increased in gastric cancer tissues compared with paired adjacent normal tissues. Moreover, high expression of BANCR was positively associated with clinical stage, tumor depth, lymph node metastasis and distant metastasis in gastric cancer patients. BANCR overexpression was an independent unfavorable prognostic biomarker for gastric cancer patients. | 26054683 | Lnc2Cancer |
| EL0229 | BC011663 | gastric cancer | microarray, qPCR etc. | primary gastric adenocarcinoma tissue | down-regulated | N/A | For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). | 24819045 | Lnc2Cancer |
| EL0244 | BLACAT1 | gastric cancer | qPCR, knockdown etc. | gastric cancer tissue, cell lines (BGC-823, SGC-7901, AGS, MKN-45, HGC-27 etc.) | up-regulated | expression | We found that linc-UBC1 was significantly upregulated in gastric cancer tissues compared to adjacent normal tissues. Furthermore, high linc-UBC1 expression was associated with lymph-node metastasis, tumor size, TNM stage and poorer prognosis. Inhibition of linc-UBC1 suppressed the proliferation, motility and invasion of gastric cancer cells.Inhibition of linc-UBC1 suppressed the proliferation, motility and invasion of gastric cancer cells. | 25755750 | Lnc2Cancer |
| EL0245 | BM742401 | gastric cancer | RNA-seq, qPCR, in vitro knockdown etc. | gastric cancer tissue, cell lines (B16F1) | down-regulated | N/A | BM742401 was downregulated in cancer, and its downregulation was associated with poor survival in gastric cancer patients. Ectopic overexpression of BM742401 inhibited metastasis-related phenotypes and decreased the concentration of extracellular MMP9. | 23846333 | Lnc2Cancer |
| EL0256 | C1orf74 | gastric cancer | qPCR, Western blot etc. | cell lines (SGC7901, BGC823, SGC7901/DDP, BGC823/DDP etc.) | up-regulated | interaction | The expression of lncRNA AK022798 was significantly higher in all pcDNA3-Notch 1 plasmid treatment groups than in the pcDNA3 plasmid treatment group (P< 0.01).Overexpression of lncRNA AK022798 promotes SGC7901/DDP and BGC823/DDP cells apoptosis.the expression of MRP1 and P-glycoprotein decreased significantly in SGC7901/DDP and BGC823/DDP cells, and their apoptosis as well as the expressions of caspase 3 and caspase 8. | 25763542 | Lnc2Cancer |
| EL0264 | CACNAICAS3 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | up-regulated | expression | The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. | 26045391 | Lnc2Cancer |
| EL0276 | CCAT1 | gastric cancer | N/A | gastric cancer (GC) cells and tissues | up-regulated | N/A | CCAT1 regulates miR-490 | 26825578 | |
| EL0276 | CCAT1 | gastric cancer | N/A | N/A | N/A | expression | Level of lncRNA CCAT1 was markedly increased in gastric carcinoma tissue comparing with normal tissue, and overexpressed CCAT1 promoted cancer cell proliferation and migration | 24757675 | LncRNADisease |
| EL0276 | CCAT1 | gastric cancer | N/A | N/A | N/A | expression | Another study reported that lncRNA CCAT1 was up-regulated in gastric carcinoma tissues, and its expression was closely related to the transcription factor c-Myc. | 24833871 | LncRNADisease |
| EL0276 | CCAT1 | gastric cancer | qPCR etc. | gastric cancer tissue | up-regulated | expression | AGS human gastric carcinoma cell line showed an elevated level of CCAT1 expression. Expression levels of CCAT1 were approximately 10.8 fold higher in GC samples than in samples taken from the negative control group. Interestingly, CCAT1 expression was significantly overexpressed in adjacent normal tissues when compared to the negative control group. Tissues obtained from recurrent GC cases showed the highest expression levels. Expression levels increased with tumor stage, however this did not reach statistical significance. | 25561974 | Lnc2Cancer |
| EL0276 | CCAT1 | gastric cancer | qPCR, Western blot, in vitro knockdown etc. | gastric cancer tissue | up-regulated | expression | In the present study, a great upregulation of CARLo-5 was observed in gastric cancer compared to paired adjacent normal tissues. Knockdown of CARLo-5 in gastric cancer cell lines significantly inhibited the cell proliferation via inducing G0/G1 cell-cycle arrest and apoptosis. | 25674211 | Lnc2Cancer |
| EL0276 | CCAT1 | gastric cancer | qPCR, Western bolt, knockdown, Luciferase reporter assay, RIP etc. | gastric carcinoma tissue, cell lines (AGS, MKN45) | up-regulated | regulation | Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma. | 23143645 | LncRNADisease Lnc2Cancer |
| EL0278 | CCAT2 | gastric cancer | qPCR, knockdown etc. | gastric cancer tissue, cell lines (BGC-823, SGC-7901, AGS, MKN-45, HGC-27 etc.) | up-regulated | expression | Expression levels of lncRNA CCAT2 in gastric cancer tissues were significantly higher than those in adjacent non-tumor tissues. By statistical analyses, high lncRNA CCAT2 expression was observed to be closely correlated with higher incidence of lymph node metastasis and distance metastasis. Moreover, patients with high lncRNA CCAT2 expression had shorter overall survival and progression-free survival compared with the low lncRNA CCAT2 group. | 25755774 | Lnc2Cancer |
| EL0289 | CDKN2B-AS1 | gastric cancer | qPCR, Western blot, knockdown, RIP etc. | gastric cancer tissue, cell lines (SGC7901, BGC823, MGC803) | up-regulated | regulation | Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. | 24810364 | LncRNADisease Lnc2Cancer |
| EL0289 | CDKN2B-AS1 | gastric cancer | silencing ; qRT-PCR and western blotting | gastric cancer tissues of cisplatin-resistant and 5-fluorouracil (5-FU)-resistant patients | up-regulated | N/A | ANRIL positively correlated with the expression in gastic cell; silencing ANRIL decreased the IC50 values in gastric cancer cells | 27121324 | |
| EL0298 | COL3A1 | gastric cancer | microarray, qPCR, knockdown etc. | gastric cancer tissue | up-regulated | N/A | LncRNA M59227 and 3 mRNAs, PLK1, PTTG1 and VCAN, were overexpressed in GC. In contrast, the expression of 4 lncRNAs, LOC150622, AKR7 L, DQ192290 and BC040587, and 2 mRNAs, DRD5 and GDF5, were downregulated in GC.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. | 25765901 | LncRNADisease Lnc2Cancer |
| EL0311 | CTD-3080P12.3 | gastric cancer | microarray, qPCR, Western blot, Luciferase reporter assay etc. | gastric cancer tissue, cell lines (KATO-III, SGC-7901, MKN28, AGS, MKN45) | up-regulated | interaction | Here, we report that BC032469, a novel lncRNA, expressed highly in gastric cancer tissues, and the upregulation was clinically associated with larger tumor size, poor differentiation and shorter survival of gastric cancer patients. Mechanistically, BC032469 could directly bind to miR-1207-5p and effectively functioned as a sponge for miR-1207-5p to modulate the derepression of hTERT. Thus, BC032469 may function as a ceRNA to impair miR-1207-5p-dependent hTERT downregulation, suggesting that it may be clinically valuable as a poor prognostic biomarker of gastric cancer. | 26549025 | Lnc2Cancer |
| EL0325 | CYTOR | gastric cancer | microarray, qPCR, Western blot, knockdown etc. | gastric cancer tissue, cell lines (HCG-27, SGC-7901) | up-regulated | expression | Linc00152 was validated to be increased in 59 paired gastric cancer specimens (Fig. 3C), and the high levels of Linc00152 expression correlated with larger tumor size. | 26237576 | Lnc2Cancer |
| EL0325 | CYTOR | gastric cancer | qPCR etc. | blood(serum) | up-regulated | expression | The levels of plasma LINC00152 were significantly elevated in gastric cancer patients compared with healthy controls. The sensitivity and specificity of plasma LINC00152 in the diagnosis of gastric cancer were 48.1 and 85.2 %, respetcively. LINC00152 levels in preoperative plasma samples were lower than those in postoperative ones. | 25391424 | Lnc2Cancer |
| EL0325 | CYTOR | gastric cancer | qPCR, Western blot, ISH, RIP, RNA pull-down assay etc. | gastric cancer tissue, cell lines (MGC803, HGC-27) | up-regulated | interaction | In this study, we first confirmed the upregulation of cytoplasmic expressed Linc00152 in 72 pair tissues of gastric patients. A suppression of cell proliferation and tumor growth was obtained in MGC803 and HGC-27 cells treated with Linc00152 shRNA. RNA pull-down and RIP assay revealed that Linc00152 could directly bind with EGFR which caused an activation of PI3K/AKT signaling. | 26538117 | Lnc2Cancer |
| EL0325 | CYTOR | gastric cancer | qPCR, Western blot, Northern blot, knockdown etc. | gastric cancer tissue, cell lines (AGS, BGC-823, MGC-803, SGC-7901 etc.) | up-regulated | N/A | The results showed that the expression level of LINC00152 in gastric carcinoma was significantly increased, compared with matched normal tissue (P=0.045) and normal mucosa from health control (P=0.004), respectively. Levels of LINC00152 in gastric cancer cell lines, BGC-823, MGC-803, and SGC-7901, were significantly higher than those in human normal gastric epithelial cell line GES-1. In addition, high expression of LINC00152 was correlated with invasion (P=0.042). LINC00152 levels in gastric juice from patients with gastric cancer were further found significantly higher than those from normal controls (P=0.002). | 24523021 | Lnc2Cancer |
| EL0342 | DKFZP434K028 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue, cell lines (HCG-27, SGC-7901) | down-regulated | expression | Linc00261, DKFZP434K028 and RPL34-AS1 had lower expression levels in gastric cancer tissues than the normal counterparts. In gastric cell lines, the three lncRNAs were also down-regulated compared with the respective normal gastric epithelial cell line GES-1. Moreover, the low expression levels of DKFZP434K028 and RPL34-AS1 positively correlated with the larger tumor size. | 26237576 | Lnc2Cancer |
| EL0353 | DMTF1 | gastric cancer | microarray, qPCR, Western blot etc. | cell lines (SGC7901) | up-regulated | N/A | We show here that the lncRNA MRUL, was significantly upregulated in two multidrug-resistant GC cell sublines, SGC7901/ADR and SGC7901/VCR. Furthermore, the relative expression levels of MRUL in GC tissues were negatively correlated with in vitro growth inhibition rates of GC specimens treated with chemotherapeutic drugs and indicated a poor prognosis for GC patients. MRUL plays a positive role in the regulation of ABCB1 expression and is a potential target to reverse the MDR phenotype of GC MDR cell sublines. | 24958102 | Lnc2Cancer |
| EL0364 | EGFLAM-AS1 | gastric cancer | qPCR, Western blot, knockdown etc. | gastric cancer tissue, cell lines (SGC-7901, AGS, BGC-823, HG-27, GES-1) | down-regulated | interaction | Significantly reduced expression of lncRNA-LOWEG was found in gastric cancer tissues and cell lines (SGC-7901, AGS, BGC-823 and HG-27) compared with patient-matched nontumorous adjacent tissues (P < 0.01) or the normal gastric cell line GES-1 (P < 0.05). Lastly, western blot and real-time PCR analysis suggested that lncRNA-LOWEG is positively correlated with the expression of leukemia inhibitory factor receptor (LIFR) gene at the translational level. | 26537802 | Lnc2Cancer |
| EL0478 | ERCC1 | gastric cancer | qPCR etc. | gastric cancer tissues, cell lines (AGS, SGC-7901, BGC-823, HG27) | down-regulated | expression | The results showed that the expression level of AC138128.1 in GC was significantly decreased compared to that in NAT. Levels of AC138128.1 in the GC cell lines, AGS BGC-823, HG27, and SGC-7901 were lower than those in the human normal gastric epithelial cell line GES-1. lncRNA AC138128.1 might be a novel biomarker for predicting GC. | 25260808 | Lnc2Cancer |
| EL0492 | FENDRR | gastric cancer | qPCR, Western blot etc. | gastric cancer tissue, cell lines (MGC803, BGC823, MKN28, MKN45, SGC7901) | down-regulated | interaction | FENDRR was downregulated in gastric cancer cell lines and cancerous tissues, as compared with normal gastric epithelial cells and adjacent noncancerous tissue samples. Low FENDRR expression was correlated with deeper tumor invasion, higher tumor stage, and lymphatic metastasis. Histone deacetylation was involved in the downregulation of FENDRR in gastric cancer cells. FENDER overexpression suppressed invasion and migration by gastric cancer cells in vitro, by downregulating FN1 and MMP2/MMP9 expression. | 25167886 | Lnc2Cancer |
| EL0494 | FER1L4 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | down-regulated | N/A | FER1L4 expression levels in gastric cancer tissues are significantly decreased. The low FER1L4 level were associated with tumor size, histologic grade, general classification, depth of invasion, lymphatic metastasis , distant metastasis, TNM stage, vessel or nerve invasion.FER1L4 might play a crucial role in human gastric cancer and may be a new potential biomarker for clinical prognosis evaluation. | 24961353 | Lnc2Cancer |
| EL0494 | FER1L4 | gastric cancer | qPCR, Western blot, knockdown etc. | gastric cancer tissue, cell lines (AGS, MGC-803, SGC-7901) | down-regulated | interaction | We observed that FER1L4 was downregulated in gastric cancer and that its level corresponded with that of PTEN mRNA. Both FER1L4 and PTEN mRNA were targets of miR-106a-5p. Further experiments demonstrated that FER1L4 downregulation liberates miR-106a-5p and decreases the abundances of PTEN mRNA and protein. More importantly, FER1L4 downregulation accelerated cell proliferation by promoting the G0/G1 to S phase transition. | 26306906 | Lnc2Cancer |
| EL0512 | FRLnc1 | gastric cancer | microarray, qPCR, knockdown etc. | gastric cancer tissue, cell lines (MGC803, AGS, BGC823, and SGC7901) | up-regulated | interaction | The RNA level of FRLnc1 is upregulated in 49 % (20/41) of cancer samples compared with neighboring non-cancerous stomach tissues. We also identified TGFb1 and Twist as the downstream effectors of FRLnc1 in the regulation of cell migration. Our findings suggest that FRLnc1 is involved in gastric cancer cell migration and for the first time set up the link between FOXM1 and LncRNA in cancer. | 25907137 | Lnc2Cancer |
| EL0518 | GACAT1 | gastric cancer | qPCR etc. | gastric cancer tissue | down-regulated | N/A | The results showed that AC096655.1-002 was significantly downregulated in gastric cancer tissues compared with paired adjacent non-tumorous tissues (P < 0.001). Its expression level was significantly correlated with lymph node metastasis (P < 0.001), distant metastasis (P < 0.001), tumor-node-metastasis stages (P < 0.001), and differentiation (P = 0.030). In a primary screen of global lncRNA expression profile in gastric cancer, we found that AC096655.1-002 (Ensembl: ENST00000419650) may contribute gastric cancer occurrence. | 23645148 | Lnc2Cancer |
| EL0519 | GACAT2 | gastric cancer | qPCR, PIR etc. | gastric cancer tissue, cell lines (AGS, BGC-823, HGC-27, MGC-803, SGC-7901 etc.) | down-regulated | N/A | The expression levels of HMlincRNA717 in five gastric cancer cell lines, AGS, BGC-823, HGC-27, MGC-803, and SGC-7901, were significantly downregulated than those in normal gastric mucosal epithelial cell line GES-1. More importantly, our results indicated that HMlincRNA717 expression levels were correlated with cancer distal metastasis (P = 0.034), venous invasion (P = 0.029), and nervous invasion (P = 0.024). lncRNA-HMlincRNA717 may play crucial roles during cancer occurrence and progression and may be a new potential biomarker of early gastric cancer. | 24961350 | Lnc2Cancer |
| EL0520 | GACAT3 | gastric cancer | qPCR etc. | gastric cancer tissue, cell lines (AGS, BGC-823, MGC-803, SGC-7901 etc.) | up-regulated | N/A | AC130710 in gastric cancer was significantly higher. Its expression level was significantly associated with tumor size, tumor-node-metastasis (TNM) stages, and distal metastasis. miR-129-5p may play an important role in the downregulation of AC130710 in gastric cancer cells. These results indicated that lncRNA-AC130710 may be a potential tumor marker for gastric cancer prognosis. | 24969565 | Lnc2Cancer |
| EL0523 | GAPLINC | gastric cancer | microarray, ISH etc. | gastric cancer tissue | up-regulated | N/A | GAPLINC is a 924-bp-long lncRNA that is highly expressed in gastric cancer tissues. GAPLINC suppression and with gene expression profiling in gastric cancer cells revealed alterations in cell migration pathways, with CD44 expression the most highly correlated. Manipulating GAPLINC | 25277524 | LncRNADisease Lnc2Cancer |
| EL0526 | GAS5 | gastric cancer | qPCR, Western blot, knockdown etc. | gastric cancer tissue, cell lines (SGC7901, BGC823, MGC803, MKN45, MKN28) | down-regulated | N/A | GAS5 expression was markedly downregulated in gastric cancer tissues. Moreover, ectopic expression of GAS5 was demonstrated to decrease gastric cancer cell proliferation and induce apoptosis, while downregulation of endogenous GAS5 could promote cell proliferation. GAS5 could influence gastric cancer cells proliferation, partly via regulating E2F1 and P21 expression. | 24884417 | Lnc2Cancer |
| EL0533 | GHET1 | gastric cancer | hypoxia-induced GC and normoxia conditions using microarrays | hypoxia-induced GC cells | up-regulated | N/A | lncRNA-AK123072/EGFR pathway in gastric cancer pathogenesis | 26884908 | |
| EL0533 | GHET1 | gastric cancer | qPCR etc. | gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) | up-regulated | expression | All the 8 lncRNAs were then subjected to qPCR validation using 20 pairs of GC and control tissues. Among them, HOTAIR, PVT1, H19, MALAT1, GHET1 and HULC were significantly higher in tumor tissues compared with control tissues. | 26096073 | Lnc2Cancer |
| EL0533 | GHET1 | gastric cancer | qPCR, Western blot, Luciferase reporter assay, knockdown, RIP etc. | gastric cancer tissue, cell lines (MKN45, AGS etc.) | up-regulated | regulation | Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability. | 24397586 | LncRNADisease Lnc2Cancer |
| EL0551 | AF181450.1 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | down-regulated | expression | The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. | 26045391 | Lnc2Cancer |
| EL0556 | H19 | gastric cancer | AGS cells, knock out of H19 | gastric cancer AGS cells | down-regulated | N/A | H19 or miR-675 enhanced RUNX1 expression | 26931432 | |
| EL0556 | H19 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue, cell lines (GES-1, AGS, MGC-803, SGC-7901) | up-regulated | N/A | As shown in Figure 2D, comparing with respective normal cell line, H19 was found highly expressed in stomach cancer cell lines (AGS, MGC-803 and SGC-7901) and hepatocellular carcinoma cell lines (SMMC-7721 and HepG2), while lowly expressed in lung cancer cell line (A549) and prostate cancer cell lines (Du-145 and PC-3). | 24063685 | Lnc2Cancer |
| EL0556 | H19 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue, cell lines (HCG-27, SGC-7901) | up-regulated | expression | H19 and HOTAIR displayed significantly higher levels and the up-regulation of HOTAIR was associated with lymphatic metastasis and poor differentiation. | 26237576 | Lnc2Cancer |
| EL0556 | H19 | gastric cancer | N/A | N/A | N/A | regulation | Using real-time RT-PCR, flow cytometry, RNA immunoprecipitation and other methods, Yang et al confirmed that H19 expression in gastric cancer accelerated cell proliferation. | 24833871 | LncRNADisease |
| EL0556 | H19 | gastric cancer | qPCR etc. | gastric cancer tissue, cell lines (HGC27) | up-regulated | N/A | Plasma H19 levels were significantly higher in patients than in healthy controls (p=0.029). Circulating lncRNAs can be detectable in plasma, and the detection of circulating lncRNAs may provide new complementary tumor markers for gastric cancer. | 23898077 | Lnc2Cancer |
| EL0556 | H19 | gastric cancer | qPCR etc. | gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) | up-regulated | expression | After validating in 20 pairs of tissues and plasma in training set, H19 was selected for further analysis in another 70 patients and 70 controls. Plasma level of H19 was significantly higher in GC patients compared with normal controls. | 26096073 | Lnc2Cancer |
| EL0556 | H19 | gastric cancer | qPCR, knockdown etc. | gastric cancer tissue, cell lines MGC-803, SGC-7901, GES-1) | up-regulated | regulation | c-Myc-induced, long, noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer. | 24671855 | LncRNADisease Lnc2Cancer |
| EL0556 | H19 | gastric cancer | qPCR, Luciferase reporter assays, in vitro knockdown, RIP etc. | gastric cancer tissue,cell lines (AGS, MKN45, MGC803, SGC7901, GES-1 etc.) | up-regulated | N/A | We demonstrated that H19 levels were markedly increased in gastric cancer cells and gastric cancer tissues compared with normal controls. Moreover, ectopic expression of H19 increased cell proliferation, whereas H19 siRNA treatment contributed to cell apoptosis in AGS cell line. We further verified that H19 was associated with p53, and that this association resulted in partial p53 inactivation. | 22776265 | Lnc2Cancer |
| EL0556 | H19 | gastric cancer | qPCR, Luciferase reporter assays, knockdown etc. | gastric cancer tissue | up-regulated | interaction | H19 expression was found to be inversely correlated to miR-141 expression in gastric cancer cells and tissues. H19 promotes malignancy including proliferation and invasion whereas miR-141 suppresses malignancy in human cancer cells. MiR-141 binds to H19 in a sequence specific manner, and suppresses H19 expression and functions including proliferation and invasion. MiR-141 could also regulate H19 target genes and miR-141 inhibitor restores H19 siRNA function, while H19 regulates miR-141 target gene ZEB1 | 26160158 | Lnc2Cancer |
| EL0556 | H19 | gastric cancer | qPCR, Western blot, knockdown etc. | gastric cancer tissue, cell lines (AGS, MGC803 etc.) | up-regulated | N/A | The expression levels of H19 and miR-675 in five gastric cancer cell lines were correlated with each other (r = 0.9910, P = 0.0315, data not shown). We next assessed the correlation of miR-675 and H19 expression in 24 human gastric cancer tissues. The expression of H19 and miR-675 in gastric cancer tissues was correlated with each other (r = 0.8214, P < 0.01). | 24388988 | Lnc2Cancer |
| EL0556 | H19 | gastric cancer | qPCR, Western blot, Luciferase reporter assays, knockdown etc. | gastric cancer tissue, cell lines (SGC7901, MKN45, MKN-28 etc.) | up-regulated | expression | Overexpression of?lncRNA?H19 enhances carcinogenesis and metastasis of gastric cancer. | 24810858 | LncRNADisease Lnc2Cancer |
| EL0556 | H19 | gastric cancer | real-time quantitative polymerase chain reaction (qPCR) assay | gastric cancer (GC) tissues | up-regulated | expression | H19 might serve as a promising biomarker for early detection and prognosis prediction of GC. | 26774144 | |
| EL0556 | H19 | gastric cancer | stratified analyses | gastric cancer samples | up-regulated | mutation | We genotyped four lncRNA H19 single nucleotide polymorphisms (SNPs)(rs217727 C > T, rs2839698 C > T, rs3741216 A > T, rs3741219 T > C) in 500 GC patients and 500 healthy controls. These findings suggest that lncRNA H19 SNPs may contribute to susceptibility to GC. | 25944697 | |
| EL0570 | HIF1A-AS2 | gastric cancer | qPCR etc. | cancerous gastric tissue, blood (serum) | up-regulated | expression | The expression of HIF1A-AS2 was upregulated in GC tumorous tissues compared with the adjacent normal tissues (P < 0.001). Its overexpression was correlated with TNM stages (P = 0.008), tumor invasion (P = 0.016), lymph node metastasis (P = 0.042), and poor prognosis (P = 0.001). | 25686741 | Lnc2Cancer |
| EL0572 | HIV1230 | gastric cancer | microarray, qPCR etc. | primary gastric adenocarcinoma tissue | down-regulated | N/A | For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). | 24819045 | Lnc2Cancer |
| EL0575 | HNF1A-AS1 | gastric cancer | microarray, qPCR etc. | GC tissue, cell lines (AGS, BGC-823, MKN-45) | down-regulated | interaction | LncRNAs microarray analysis results exhibited that HNF1A-AS1 was downregulated in GCs tissues (mean fold change 2.06, p < 0.05), which was further confirmed by qRT-PCR. The results from qRT-PCR showed that the expression of HNF1A-AS1 was not only downregulated in three GC cell lines (AGS, BGC-823, and MKN-45) relative to that in a normal gastric mucosal epithelial cell line (GES-1), but also decreased in GC tissues relative to that in paired adjacent non-neoplastic tissues (low expression, 94 of 161; low expression rate, 58.38%). Furthermore, low HNF1A-AS1 expression was associated with tumor size/diameter (p = 0.005, multivariate analysis), levels of serum carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9), and RRM1 expression in tissue samples | 26472090 | Lnc2Cancer |
| EL0578 | HOTAIR | gastric cancer | microarray, qPCR etc. | gastric cancer tissue, cell lines (HCG-27, SGC-7901) | up-regulated | expression | H19 and HOTAIR displayed significantly higher levels and the up-regulation of HOTAIR was associated with lymphatic metastasis and poor differentiation. | 26237576 | Lnc2Cancer |
| EL0578 | HOTAIR | gastric cancer | N/A | gastric cancer cell lines and tissue samples | up-regulated | locus/expression | We found that the HOTAIR rs920778 TT carriers had a 1.66- and 1.87-fold increased gastric cancer risk in Jinan and Huaian populations compared with the CC carriers. | 25640751 | |
| EL0578 | HOTAIR | gastric cancer | N/A | N/A | N/A | expression | Upregulation of HOTAIR is associated with metastasis of gastric cancer, lung cancer, and esophageal squamous cell carcinoma? | 24757675 | LncRNADisease |
| EL0578 | HOTAIR | gastric cancer | qPCR etc. | gastric cancer tissue | up-regulated | N/A | The expression of HOTAIR was markedly increased in gastric cancer tissues compared with adjacent non-tumoral tissues. We further showed that there was a positive significant correlation between the HOTAIR gene expression, TNM staging, perineural invasion, and distant metastasis, but not with other clinicopathological features of gastric tumors. HOTAIRexpression is modulated during gastric cancer progression and therefore may participate in molecular processes relevant to malignant transformation and metastasis in gastric carcinoma. | 24949306 | Lnc2Cancer |
| EL0578 | HOTAIR | gastric cancer | qPCR etc. | gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) | up-regulated | expression | All the 8 lncRNAs were then subjected to qPCR validation using 20 pairs of GC and control tissues. Among them, HOTAIR, PVT1, H19, MALAT1, GHET1 and HULC were significantly higher in tumor tissues compared with control tissues. | 26096073 | Lnc2Cancer |
| EL0578 | HOTAIR | gastric cancer | qPCR, knockdown etc. | gastric cancer tissue, cell lines(MKN74, KATO III etc.) | up-regulated | N/A | The expression of HOTAIR was significantly higher in cancer lesions than in adjacent non-cancerous tissues in human gastric cancers. In the diffuse type of gastric cancer, the High-HOTAIR group (HOTAIR/GAPDH > 1) showed significantly more venous invasion, frequent lymph node metastases and a lower overall survival rate compared to the Low-HOTAIR group (HOTAIR/GAPDH < 1). | 24130837 | Lnc2Cancer |
| EL0578 | HOTAIR | gastric cancer | qPCR, knockdown etc. | gastric cancer tissue, cell lines (MKN7, MKN45, MKN74, NUGC4, AZ521, AGS, KATOIII) | up-regulated | interaction | Expression of both lncRNAs was significantly higher in cancerous tissues than in corresponding normal mucosa, and higher expression of these lncRNAs significantly correlated with peritoneal metastasis in GC patients. In addition, elevated HOTAIR expression emerged both as an independent prognostic and risk factor for peritoneal dissemination. SiRNA knockdown of HOTAIR in GC cells significantly inhibited cell proliferation, migration and invasion, but concurrently enhanced the anoikis rate in transfetced cells. | 25280565 | Lnc2Cancer |
| EL0578 | HOTAIR | gastric cancer | qPCR, Luciferase reporter assay, knockdown, ELISA etc. | gastric cancer tissue, cell lines (SGC7901, MGC-803) | up-regulated | interaction | Significant HOTAIR overexpression was observed in GC tissues, as well as strong positive correlations with HLA-G levels in both tissue and peripheral blood samples. HOTAIR overexpression might also get involved in tumor escape mechanisms, involving HLA-G upregulation via inhibiting miR-152. | 26187665 | Lnc2Cancer |
| EL0578 | HOTAIR | gastric cancer | qPCR, Northern blot, knockdown etc. | gastric cancer tissue | up-regulated | N/A | HOTAIR Long Noncoding RNA Promotes Gastric Cancer Metastasis through Suppression of Poly r(C)-Binding Protein (PCBP) 1. Our findings provide mechanistic evidence for HOTAIR overexpression and PCBP1 downregulation and the ensuing malignant phenotype in both cultured and xenograft gastric cancer cells. | 25612617 | LncRNADisease Lnc2Cancer |
| EL0578 | HOTAIR | gastric cancer | qPCR, Western blot etc. | gastric cancer tissue, gastric cell lines | up-regulated | interaction | The expression of HOTAIR was significantly elevated in various gastric cancer cell lines and tissues compared to normal control. Lymphovascular invasion and lymph node metastasis were more common in the high level of HOTAIR group. si-HOTAIR significantly decreased invasiveness and migration. si-HOTAIR led to differential expression of epithelial to mesenchymal transition markers. HOTAIR was involved in inhibition of apoptosis and promoted invasiveness, supporting a role for HOTAIR in carcinogenesis and progression of gastric cancer. | 25063030 | Lnc2Cancer |
| EL0578 | HOTAIR | gastric cancer | qPCR, Western blot, Luciferase reporter assay, knockdown etc. | gastric cancer tissue, cell lines (MGC-803, SGC-7901, BGC-823, AGS) | up-regulated | regulation | Lnc RNA HOTAIR functions as a competing endogenous?RNA?to regulate HER2 expression by sponging miR-331-3p in gastric cancer. | 24775712 | LncRNADisease Lnc2Cancer |
| EL0578 | HOTAIR | gastric cancer | qPCR, Western bolt, in vitro knockdown etc. | gastric cancer tissue, cell lines (GES-1, AGS, SGC-7901, MKN-45, HGC-27 etc.) | up-regulated | N/A | The expression level of HOTAIR in cancer tissues was higher than that in adjacent noncancerous tissues. Expression level of HOTAIR was significantly correlated with lymph node metastasis and TNM stage. Furthermore, high expression level of HOTAIR was a predictor of poor over-all survival in GC patients. In vitro, inhibition of HOTAIR in GC cells could reduce invasiveness, as well as the expression of MMP1 and MMP3. In addition, suppression of HOTAIR could reverse EMT process. | 23847441 | Lnc2Cancer |
| EL0578 | HOTAIR | gastric cancer | TaqMan RT-PCR | gastric cancer samples | N/A | mutation | A naturally occurring functional single nucleotide polymorphism (SNP) rs920,778 (C→T) in the intronic enhancer of HOTAIR gene has been demonstrated to affect HOTAIR expression and cancer susceptibility. Our results demonstrate that the HOTAIR rs920778 polymorphism has not been in any major role in genetic susceptibility to gastric carcinogenesis, at least in the population studied here. | 25980897 | |
| EL0588 | HOXA-AS2 | gastric cancer | microarray, qPCR, Western blot, Luciferase reporter assay etc. | gastric cancer tissue, cell lines (BGC823, SGC7901, AGS) | up-regulated | interaction | Here, we reported that HOXA cluster antisense RNA2 (HOXA-AS2), a 1048bp RNA, was upregulated in GC. Increased HOXA-AS2 expression in GC was associated with larger tumor size and higher clinical stage; patients with higher levels of HOXA-AS2 expression had a relatively poor prognosis. HOXA-AS2 could be an oncogene for GC partly through suppressing P21, PLK3, and DDIT3 expression; HOXA-AS2 may be served as a candidate prognostic biomarker and target for new therapies in human GC. | 26384350 | Lnc2Cancer |
| EL0600 | HULC | gastric cancer | qPCR etc. | gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) | up-regulated | expression | All the 8 lncRNAs were then subjected to qPCR validation using 20 pairs of GC and control tissues. Among them, HOTAIR, PVT1, H19, MALAT1, GHET1 and HULC were significantly higher in tumor tissues compared with control tissues. | 26096073 | Lnc2Cancer |
| EL0600 | HULC | gastric cancer | qPCR, Western blot etc. | gastric cancer tissue, cell lines (GES-1, SGC7901, MKN28, MKN45, AGS, BGC823 etc.) | up-regulated | N/A | In the present study, we demonstrated that HULC was significantly overexpressed in GC cell lines, compared with normal controls, and this overexpression was correlated with lymph node metastasis, distant metastasis and advanced tumor node metastasis stages.Additionally, HULC contributed to the malignant phenotype of GC cells through its regulation of diverse cellular processes, including proliferation, apoptosis, migration and invasion. | 24247585 | Lnc2Cancer |
| EL0611 | INTS7 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | up-regulated | expression | The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. | 26045391 | Lnc2Cancer |
| EL0624 | KCNE2 | gastric cancer | microarray, qPCR, knockdown etc. | gastric cancer tissue | down-regulated | N/A | LncRNA M59227 and 3 mRNAs, PLK1, PTTG1 and VCAN, were overexpressed in GC. In contrast, the expression of 4 lncRNAs, LOC150622, AKR7 L, DQ192290 and BC040587, and 2 mRNAs, DRD5 and GDF5, were downregulated in GC.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. | 25765901 | LncRNADisease Lnc2Cancer |
| EL0634 | KRT18P55 | gastric cancer | N/A | GC cell lines (SGC-7901, MGC-803, BGC-823, AGS, and HG27) and 97 GC tissue | up-regulated | N/A | upregulation was observed in GC cell lines | 26855593 | |
| EL0644 | LEIGC | gastric cancer | microarray, qPCR, in vitro knockdown etc. | gastric cancer tissue, cell lines (MGC-803, AGS, SGC-7901) | up-regulated | expression | We found that there were significantly lower levels of LEIGC expression in gastric cancer tissue. Overexpression of LEIGC suppressed tumor growth and cell proliferation, and enhanced the sensitivity of gastric cancer cells to 5-fluorouracil (5-FU), whereas knockdown of LEIGC showed the opposite effetc. We further demonstrated LEIGC functions by inhibiting the epithelial-to-mesenchymal transition (EMT) in gastric cancer. | 25496320 | Lnc2Cancer |
| EL0651 | LINC00261 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue, cell lines (HCG-27, SGC-7901) | down-regulated | expression | Linc00261, DKFZP434K028 and RPL34-AS1 had lower expression levels in gastric cancer tissues than the normal counterparts. In gastric cell lines, the three lncRNAs were also down-regulated compared with the respective normal gastric epithelial cell line GES-1. Moreover, the low expression levels of DKFZP434K028 and RPL34-AS1 positively correlated with the larger tumor size. | 26237576 | Lnc2Cancer |
| EL0666 | LINC00668 | gastric cancer | knockdown | n vitro and in vivo | up-regulated | N/A | LINC00668 knockdown significantly repressed proliferation, both in vitro and in vivo | 27036039 | |
| EL0670 | LINC00901 | gastric cancer | microarray, qPCR, knockdown etc. | gastric cancer tissue | down-regulated | N/A | LncRNA M59227 and 3 mRNAs, PLK1, PTTG1 and VCAN, were overexpressed in GC. In contrast, the expression of 4 lncRNAs, LOC150622, AKR7 L, DQ192290 and BC040587, and 2 mRNAs, DRD5 and GDF5, were downregulated in GC.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. | 25765901 | LncRNADisease Lnc2Cancer |
| EL0677 | LINC00982 | gastric cancer | qPCR, Western blot, Luciferase reporter assay, knockdown, RIP etc. | gastric cancer tissue, cell lines (SGC7901, BGC823, MGC803, AGS, MKN45) | down-regulated | interaction | In this study, we identified a novel lncRNA LINC00982, whose expression was downregulated in tumor tissues in 106 patients with gastric cancer (GC) compared with those in the adjacent normal tissues (P < 0.001). Furthermore, knockdown of LINC00982 expression by small interfering RNA (siRNA) could promote cell proliferation and cell cycle progression, while ectopic expression of LINC00982 inhibited cell proliferation and rendered cell cycle arrest in GC cells partly via regulating P15 and P16 protein expressions. | 26334618 | Lnc2Cancer |
| EL0684 | LINC01105 | gastric cancer | microarray, qPCR, knockdown etc. | gastric cancer tissue | down-regulated | N/A | LncRNA M59227 and 3 mRNAs, PLK1, PTTG1 and VCAN, were overexpressed in GC. In contrast, the expression of 4 lncRNAs, LOC150622, AKR7 L, DQ192290 and BC040587, and 2 mRNAs, DRD5 and GDF5, were downregulated in GC.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. | 25765901 | LncRNADisease Lnc2Cancer |
| EL0687 | LINC01158 | gastric cancer | microarray, qRT-PCR | peripheral blood regulatory T cells (T-reg) in gastric cancer | up-regulated | interaction | linc-POU3F3 could promote the distribution of Tregs in peripheral blood T cell which caused an enhanced cell proliferation of gastric cancer cells by recruiting TGF-beta as well as activating TGF-beta signal pathway. | 26807174 | |
| EL0747 | LINC-ROR | gastric cancer | qPCR, Western blot, knockdown etc. | cell line (AGS) | up-regulated | expression | we found that the expression of ROR was significantly increased in a series of tumor cells, whereas all of the negative controls remained weakly expressed. | 26169368 | Lnc2Cancer |
| EL0798 | LncRNA-AP001631.9 | gastric cancer | qPCR, knockdown etc. | gastric cancer tissue, cell lines (AGS, MGC803, BGC823, SGC7901) | up-regulated | expression | The qRT-PCR data indicated that the LncRNA-AP001631.9 expression was frequently increased in gastric cancer tissues. The expression level of LncRNA-AP001631.9 was positively correlated with that of FOXM1. The transwell and wound healing assays indicated that LncRNA-AP001631.9 was required for the migration of gastric cancer cells. The downregulation of LncRNA-AP001631.9 by small interference RNA suppressed the migratory ability of MGC803 and AGS cells, while the overexpression of LncRNA-AP001631.9 promoted the movement of BGC823 and SGC7901 cells. | 26261500 | Lnc2Cancer |
| EL0799 | lncRNA-ATB | gastric cancer | qPCR etc. | gastric cancer tissue, cell lines (MKN1, MKN7, MKN28, MKN45, MKN74 etc.) | differential expression | interaction | The high lncRNA-ATB group experienced a lower overall survival rate compared with the low lncRNA-ATB group, and multivariate analysis indicated that lncRNA-ATB was an independent prognostic factor (hazard ratio 3.50; 95 % CI 1.73-7.44; p = 0.0004).LncRNA-ATB plays an important role in EMT to promote invasion and metastasis through the TGFb/miR-200s/ZEB axis, resulting in a poor prognosis in GC.LncRNA-ATB is a novel biomarker of lncRNA, indicative of a poor prognosis in GC patients. | 25986864 | Lnc2Cancer |
| EL0843 | LSINCT5 | gastric cancer | qPCR etc. | gastric cancer tissue, cell lines (AGS, MKN-45, MGC-803, BGC-823, HGC-27) | up-regulated | N/A | The expression of LSINCT5 is significantly upregulated in gastrointestinal cancer tissues and cell lines relative to their normal counterparts. In addition, increased LSINCT5 expression was correlated with a larger tumor size, deeper tumor depth, and advanced clinical stage. | 25526476 | LncRNADisease Lnc2Cancer |
| EL0843 | LSINCT5 | gastric cancer | qPCR etc. | cancerous gastric tissue, blood (serum) | up-regulated | expression | A three-lncRNA signature, including CUDR, LSINCT-5 and PTENP1, was identified that may be potential diagnostic marker for GC. Moreover, a risk model for the serum three-lncRNA signature demonstrated that healthy samples can be distinguished from early GC samples. Three-lncRNA signature in serum was identified as diagnostic marker for GC. | 25694351 | Lnc2Cancer |
| EL0851 | M14574 | gastric cancer | microarray, qPCR etc. | primary gastric adenocarcinoma tissue | down-regulated | N/A | For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). | 24819045 | Lnc2Cancer |
| EL0853 | MALAT1 | gastric cancer | qPCR etc. | gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) | up-regulated | expression | All the 8 lncRNAs were then subjected to qPCR validation using 20 pairs of GC and control tissues. Among them, HOTAIR, PVT1, H19, MALAT1, GHET1 and HULC were significantly higher in tumor tissues compared with control tissues. | 26096073 | Lnc2Cancer |
| EL0853 | MALAT1 | gastric cancer | qPCR, knockdown etc. | gastric cancer tissue, cell lines (MKN7, MKN45, MKN74, NUGC4, AZ521, AGS, KATOIII) | up-regulated | interaction | Expression of both lncRNAs was significantly higher in cancerous tissues than in corresponding normal mucosa, and higher expression of these lncRNAs significantly correlated with peritoneal metastasis in GC patients. Elevated HOTAIR expression emerged both as an independent prognostic and risk factor for peritoneal dissemination. SiRNA knockdown of HOTAIR in GC cells significantly inhibited cell proliferation, migration and invasion, but concurrently enhanced the anoikis rate in transfetced cells. | 25280565 | Lnc2Cancer |
| EL0853 | MALAT1 | gastric cancer | qPCR, Western blot, knockdown etc. | cell lines (SGC-7901, MKN-45, SUN-16) | up-regulated | N/A | In this study, we found that MALAT1 was aberrantly highly expressed in GC cell lines (SGC-7901, MKN-45 and SUN-16), and induced specific distribution and over-expression of SF2/ASF in nucleolus. Knock-down of MALAT1 or SF2/ASF in SGC-7901 cells respectively induced significant arrest of cell cycle in G0/G1 phase along with a remarkable suppression of cell proliferation, and the nuclear distribution and expression of SF2/ASF was significantly impaired when MALAT1 was depleted. However, over-expression of SF2/ASF exhibited no effect on rescuing the cell proliferation suppression by MALAT1 depletion. | 24857172 | Lnc2Cancer |
| EL0853 | MALAT1 | gastric cancer | RNA immunoprecipitation RIP-seq | gastric cancer cell lines | N/A | N/A | suppresses the tumor suppressor PCDH10 and promotes gastric cellular migration and invasion | 26871474 | |
| EL0855 | MALAT2 | gastric cancer | qPCR, Western blot etc. | gastric cancer tissue | up-regulated | N/A | MALAT2-activated long noncoding RNA indicates a biomarker of poor prognosis in gastric cancer. MALAT2 was frequently over-expressed in cancer tissues and this over-expression was found to significantly correlate with lymph node metastasis and tumor stage. | 25721209 | LncRNADisease Lnc2Cancer |
| EL0861 | MEG3 | gastric cancer | qPCR, Luciferase reporter assay, RNA pull-down assay etc. | gastric cancer tissue, cell lines (MGC-803, HGC-27, MKN-45, SGC-7901, BGC-823, AGS) | down-regulated | interaction | MEG3 is decreased in GC patients and cell lines, and its expression was associated with metastatic GC. Furthermore, ectopic expression of MEG3 in HGC-27 and MGC-803 cells inhibited cell proliferation, migration, invasion, and promoted cell apoptosis, which might be due to MEG3 sequestering oncogenic miR-181 s in GC cells. Furthermore, MEG3 could up-regulated Bcl-2 via its competing endogenous RNA (ceRNA) activity on miR-181a. | 26253106 | Lnc2Cancer |
| EL0861 | MEG3 | gastric cancer | qPCR, Western blot etc. | gastric cancer tissue, cell line (GES-1) | down-regulated | interaction | We found that expression of both miR-141 and MEG3 was significantly reduced in GC compared with levels in matched nonmalignant tissues. Positive correlation between miR-141 and MEG3 was found in both tumor tissues and control tissues. Furthermore, the over-expression of either miR-141 or MEG3 in 7901 and MKN45 cells inhibited cell proliferation and cell cycle progression and promoted cell apoptosis. E2F3 was identified as a target of miR-141, and its inhibition significantly reduced MEG3 expression. E2F3 over-expression partly reversed the changes caused by transfection of miR-141 mimic, and inhibition of miR-141 or MEG3 overrides MEG3- or miR-141-induced modulation of cell growth in GC. | 26233544 | Lnc2Cancer |
| EL0861 | MEG3 | gastric cancer | qPCR, Western blot, knockdown etc. | gastric cancer tissue, cell lines (SGC-7901, BGC-823, GES-1 etc.) | down-regulated | N/A | We examined the expression of MEG3 in 52 gastric cancer samples using quantitative qPCR and found the down-regulation of MEG3 in both gastric cancer tissues and cell lines. The positive correlation of MEG3 and miR-148a was further confirmed in SGC-7901 and BGC-823 gastric cancer cell lines. Hypermethylation of MEG3 differentially methylated regions was identified by methylation-specific PCR, and MEG3 expression was increased with the inhibition of methylation with siRNA to DNMT-1 in gastric cancer cells. In addition, transfection of MEG3 siRNA into gastric cancer cells diminished the suppression of proliferation induced by overexpression of miR-148a. | 24515776 | Lnc2Cancer |
| EL0861 | MEG3 | gastric cancer | qPCR, Western bolt, knockdown etc. | gastric cancer tissue, cell lines (SGC7901, AGS, MGC803, MKN45, BGC823 etc.) | down-regulated | expression | Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer. | 24006224 | LncRNADisease Lnc2Cancer |
| EL0872 | MINA | gastric cancer | N/A | N/A | N/A | regulation | Dysfunction of MDIG was found in several types of solid cancers including gastric carcinoma, esophageal squamous cell carcinoma, and lung cancer. Overexpression of MDIG was observed in hepatocellular carcinoma.? | 24757675 | LncRNADisease |
| EL0880 | MIR31HG | gastric cancer | qPCR, Western blot, knockdown etc. | gastric cancer tissue, cell lines (SGC7901, BGC823, MGC803, MKN45, GES-1) | down-regulated | interaction | We found that MIR31HG expression is decreased in gastric cancer tissues and associated with larger tumor size and advanced pathological stage. Patients with lower MIR31HG expression had a relatively poor prognosis. Furthermore, ectopic over-expression of MIR31HG could inhibit gastric cancer (GC) cell proliferation both in vitro and in vivo, while knockdown of MIR31HG by small interfering RNA (siRNA) promoted cell proliferation in GC cells partly via regulating E2F1 and p21 expression. | 26692098 | Lnc2Cancer |
| EL0955 | MYLK-AS1 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | down-regulated | expression | The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. | 26045391 | Lnc2Cancer |
| EL0969 | NCRUPAR | gastric cancer | qPCR etc. | gastric cancer tissue | down-regulated | N/A | The level of ncRuPAR in gastric cancer was low, and its expression level was associated with invasion depth, lymph node metastasis, distant metastasis, tumor size, and TNM stage. These findings indicate that ncRuPAR might be a potential marker for gastric cancer diagnosis. ncRuPAR might also be a tumor suppressor because it regulates the expression of PAR-1. | 24817013 | Lnc2Cancer |
| EL0973 | NEAT1 | gastric cancer | gastric cancer samples and cell lines by real-time PCR | gastric cancer tissues and cell lines | up-regulated | N/A | LncRNA NEAT1 was overexpressed in gastric cancer tissues and cell lines and corrected with clinical stage, histological type, lymph node metastasis, and distant metastasis | 27095450 | |
| EL1007 | NPTN-IT1 | gastric cancer | qPCR etc. | gastric cancer tissue | down-regulated | expression | We found that lncRNA LET expression was markedly down-regulated in tumor tissues compared with adjacent non-tumor tissues, and associated with depth of invasion, lymph node metastasis, distant metastasis, and TNM stage. Univariate and multivariate analyses showed that low lncRNA LET expression was an independent poor prognostic factor for gastric cancer patients. | 25674261 | Lnc2Cancer |
| EL1021 | OR3A4P | gastric cancer | microarray analysis qRT-PCR | gastric cancer cells | up-regulated | N/A | significantly associated with lymphatic metastasis; OR3A4 promoted cancer cell growth | 26863570 | |
| EL1046 | PANDAR | gastric cancer | Quantitative Real-time PCR | 100 paired gastric cancer tissues | up-regulated | N/A | high expression of PANDAR was correlated with depth of invasion, TNM stage and lymphatic metastasis | 26898439 | |
| EL1088 | PRNCR1 | gastric cancer | qPCR etc. | gastric cancer tissue | differential expression | mutation | We found that patients with the rs13252298AG genotype displayed a 1.50-fold increased risk of GC. Interestingly, the rs7007694CT and CC and the rs1456315GG genotypes displayed a decreased risk of GC. Our results suggest that SNPs in the lncRNA PRNCR1 may be a biomarker for the etiology of GC | 26206497 | Lnc2Cancer |
| EL1090 | PRSS21 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | up-regulated | expression | The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. | 26045391 | Lnc2Cancer |
| EL1097 | PTENP1 | gastric cancer | qPCR etc. | cancerous gastric tissue, blood (serum) | up-regulated | expression | A three-lncRNA signature, including CUDR, LSINCT-5 and PTENP1, was identified that may be potential diagnostic marker for GC. Moreover, a risk model for the serum three-lncRNA signature demonstrated that healthy samples can be distinguished from early GC samples. Three-lncRNA signature in serum was identified as diagnostic marker for GC. | 25694351 | Lnc2Cancer |
| EL1102 | PVT1 | gastric cancer | microarray, qPCR etc. | gastric cancer tissues, cell lines (SGC7901) | up-regulated | expression | PVT1 showed higher expression in human gastric cancer tissues than in adjacent non-cancerous tissues and in SGC7901 paclitaxel-resistant cells compared with SGC7901 cells. PVT1 expression was correlated with lymph node invasion of gastric cancer. | 25258543 | Lnc2Cancer |
| EL1102 | PVT1 | gastric cancer | qPCR etc. | gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) | up-regulated | expression | All the 8 lncRNAs were then subjected to qPCR validation using 20 pairs of GC and control tissues. Among them, HOTAIR, PVT1, H19, MALAT1, GHET1 and HULC were significantly higher in tumor tissues compared with control tissues. | 26096073 | Lnc2Cancer |
| EL1102 | PVT1 | gastric cancer | qPCR, Western blot etc. | gastric cancer tissue, cell lines (BGC823, SGC7901 etc.) | up-regulated | N/A | Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance | 25956062 | LncRNADisease Lnc2Cancer |
| EL1102 | PVT1 | gastric cancer | QRT-PCR assay | 111pairs of gastric cancer and adjacent normal tissues | up-regulated | N/A | up-regulation was significantly correlated to invasion depth and regional lymph nodes metastasis | 26925791 | |
| EL1102 | PVT1 | gastric cancer | qRT-PCR, MTT and colony formation assays, RIP | GC tissues and cell lines | up-regulated | expression | The higher expression of PVT1 was significantly correlated with deeper invasion depth and advanced TNM stage. Further experiments demonstrated that PVT1 knockdown significantly inhibited the proliferation both in vitro and in vivo. These results suggest that lncRNA PVT1 may serve as a candidate prognostic biomarker and target for new therapies in human gastric cancer. | 25890171 | |
| EL1120 | RN7SK | gastric cancer | N/A | N/A | N/A | expression | Transfection of an siRNA directed against LARP7 (anti-LARP7 siRNA) into non-neoplastic gastric epithelial cells decreased 7sk levels by 72% relative to a control siRNA (P<0.01). | 22488152 | LncRNADisease |
| EL1133 | RP11-119F7.4 | gastric cancer | qPCR etc. | gastric cancer tissue | down-regulated | expression | RP11-119F7.4 expression was significantly downregulated in the gastric cancer tissues compared with the matched NATs (P<0.001) and was significantly associated with the macroscopic type (P=0.041) and Lauren grade (P=0.020). LncRNA RP11-119F7.4 may be involved in carcinogenesis and may prove useful as a biomarker for diagnosis and prognostic significance in patients with gastric cancer. | 26170986 | Lnc2Cancer |
| EL1149 | AL138930.1 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | down-regulated | expression | The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. | 26045391 | Lnc2Cancer |
| EL1151 | AC104590.1 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | down-regulated | expression | The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. | 26045391 | Lnc2Cancer |
| EL1154 | LINC01612 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | down-regulated | interaction | The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. | 26045391 | Lnc2Cancer |
| EL1168 | RPL34-AS1 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue, cell lines (HCG-27, SGC-7901) | down-regulated | expression | Linc00261, DKFZP434K028 and RPL34-AS1 had lower expression levels in gastric cancer tissues than the normal counterparts. In gastric cell lines, the three lncRNAs were also down-regulated compared with the respective normal gastric epithelial cell line GES-1. Moreover, the low expression levels of DKFZP434K028 and RPL34-AS1 positively correlated with the larger tumor size. | 26237576 | Lnc2Cancer |
| EL1174 | RUNX1-IT1 | gastric cancer | microarray and quantitative real-time polymerase chain reaction (qRT-PCR), over-expression | metastatic lymph node tissues and normal lymph node tissues | up-regulated | expression | The expression levels of C21orF96 were associated with gross appearance, lymphatic metastasis and distal metastasis. C21orF96 promoted the tubular formation, migration and invasion. | 26567621 | |
| EL1214 | SLCO5A1 | gastric cancer | microarray, qPCR etc. | primary gastric adenocarcinoma tissue | up-regulated | N/A | For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). | 24819045 | Lnc2Cancer |
| EL1219 | SNCG | gastric cancer | microarray, qPCR, in vitro knockdown etc. | gastric cancer tissue, cell lines (SGC7901, MKN45, MKN28) | up-regulated | regulation | AK058003 is frequently upregulated in GC samples and promotes GC migration and invasion in vivo and in vitro. Next, we identified γ-synuclein. (SNCG), which is a metastasis-related gene regulated by AK058003. In addition, we found that the expression of SNCG is positively correlated with that of AK058003 in the clinical GC samples used in our study. Furthermore, we found that the SNCG gene CpG island methylation was significantly increased in GC cells depleted of AK058003. Intriguingly, SNCG expression is also increased by hypoxia, and SNCG upregulation by AK058003 mediates hypoxia-induced GC cell metastasis. | 25499222 | Lnc2Cancer |
| EL1225 | SNHG15 | gastric cancer | qPCR, Western blot, knockdown etc. | gastric adenocarcinoma cancer cell lines (SGC7901, BGC823, MGC803, AGS, MKN45, GES-1) | up-regulated | interaction | We identified a novel lncRNA SNHG15, whose expression was upregulated in tumor tissues in 106 patients with gastric cancer (GC) compared with those in the adjacent normal tissues (P < 0.001). Furthermore, increased SNHG15 expression was positively correlated with invasion depth (P < 0.001), advanced tumor node metastasis (TNM) stage (P = 0.001), and lymph node metastasis (P = 0.019). SNHG15 levels were robust in differentiating GC tissues from controls (area under the curve (AUC) = 0.722; 95 % confidence interval (CI) = 0.657-0.782, P < 0.01). Kaplan-Meier analysis demonstrated that elevated SNHG15 expression contributed to poor overall survival (P < 0.01) and disease-free survival (P < 0.01) of patients. A multivariate survival analysis also indicated that SNHG15 could be an independent prognostic marker. Furthermore, knockdown of SNHG15 expression by siRNA could inhibit cell proliferation and invasion and induce apoptosis, while ectopic expression of SNHG15 promoted cell proliferation and invasion in GC cells partly via regulating MMP2 and MMP9 protein expression | 26662309 | Lnc2Cancer |
| EL1240 | SPRY4-IT1 | gastric cancer | qPCR, Western blot, knockdown etc. | gastric cancer tissue, cell lines AGS, BGC-823, HGC-27, SGC-7901, MGC80-3, MKN-45) | up-regulated | N/A | SPRY4-IT1 expression was elevated in GC tissues and cell lines | 25835973 | LncRNADisease Lnc2Cancer |
| EL1240 | SPRY4-IT1 | gastric cancer | qPCR, Western blot, knockdown etc. | gastric cancer tissue, cell lines (SGC7901, BGC823, MGC803, AGS, MKN45 etc.) | down-regulated | expression | SPRY4-IT1 expression is decreased in gastric cancer tissues and associated with larger tumor size, advanced pathological stage, deeper depth of invasion and lymphatic metastasis. Patients with lower SPRY4-IT1 expression had a relatively poor prognosis. DNA methylation may be a key factor in controlling the SPRY4-IT1 expression. Furthermore, SPRY4-IT1 contributed to gastric cancer cells metastasis might partly via regulating epithelial-mesenchymal transition (EMT) process. | 26238992 | Lnc2Cancer |
| EL1250 | SUMO1P3 | gastric cancer | N/A | N/A | N/A | expression | Pseudogene-expressed lncRNAs are a major member of the lncRNA family. Recently, our group reported that small ubiquitin-like modifier (SUMO) 1 pseudogene 3, SUMO1P3, was markedly up-regulated in gastric cancer tissues compared with paired adjacent non-tumor tissues. | 24833871 | LncRNADisease |
| EL1250 | SUMO1P3 | gastric cancer | qPCR etc. | gastric cancer tissue | up-regulated | regulation | Up-regulation of SUMO1 pseudogene 3 (SUMO1P3) in gastric cancer and its clinical association. | 23996296 | LncRNADisease Lnc2Cancer |
| EL1336 | TINCR | gastric cancer | RNA-seq, qPCR, Western blot, knockdown etc. | gastric cancer tissue, cell lines (MGC803, BGC823, MKN45, SGC7901 etc.) | up-regulated | N/A | TINCR is strongly upregulated in human gastric carcinoma (GC), where it was found to contribute to oncogenesis and cancer progression. TINCR overexpression is induced by nuclear transcription factor SP1. TINCR contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease. | 25728677 | LncRNADisease Lnc2Cancer |
| EL1370 | TSNAX-DISC1 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | up-regulated | expression | The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. | 26045391 | Lnc2Cancer |
| EL1399 | TUG1 | gastric cancer | knockdown of TUG1 repressed GC proliferation | non-small cell lung cancer | up-regulated | N/A | TUG1 was associated with PRC2 | 26913601 | |
| EL1402 | TUSC7 | gastric cancer | microarray, qPCR, knockdown etc. | gastric cancer tissue | down-regulated | N/A | The results indicated that TUSC7 was downregulated in GC samples and was an independent prognostic indicator of disease-free survival (DFS) and disease-specific survival (DSS) in GC patients.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. | 25765901 | LncRNADisease Lnc2Cancer |
| EL1410 | uc.341 | gastric cancer | microarray, qPCR etc. | primary gastric adenocarcinoma tissue | up-regulated | N/A | For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). | 24819045 | Lnc2Cancer |
| EL1416 | uc001lsz | gastric cancer | microarray, qPCR etc. | gastric cancer tissue, cell lines (GES-1, AGS, MGC-803, SGC-7901) | down-regulated | N/A | The most down-regulated lncRNAs in gastric cancer tissues were FER1L4, uc001lsz, BG491697, AF131784, uc009ycs, BG981369, AF147447, HMlincRNA1600, and AK054588; while the most up-regulated ones were H19, HMlincRNA717, BM709340, BQ213083, AK054978, and DB077273. | 24063685 | Lnc2Cancer |
| EL1422 | uc003iqu | gastric cancer | microarray, qPCR etc. | primary gastric adenocarcinoma tissue | up-regulated | N/A | For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). | 24819045 | Lnc2Cancer |
| EL1424 | uc003tfx | gastric cancer | microarray, qPCR etc. | primary gastric adenocarcinoma tissue | up-regulated | N/A | For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). | 24819045 | Lnc2Cancer |
| EL1431 | UCA1 | gastric cancer | microarray assay, real-time PCR assay | gastric tumor samples | N/A | expression | There was a significantly positive correlation of UCA1 expression levels between tumor tissues and plasma (r = 0.931). Plasma UCA1 provided the higher diagnostic performance for detection of GC (AUC = 0.928; P < 0.001) than PVT-1 (AUC = 0.731; P < 0.01). Plasma UCA1 levels could be a promising candidate of noninvasive biomarker for GC early diagnosis. | 26722487 | |
| EL1431 | UCA1 | gastric cancer | microarray, RT-PCR | gastric tumor samples | up-regulated | expression | The expression level of 4 lncRNAs: UCA1, lincRNA-BBOX1-2, CR594506 and BC015134 were further confirmed in another cohort of 10 gastric patients by real-time PCR assay. A coding-non-coding co-expression network revealed that the four validated lncRNAs were correlated with twenty-six mRNAs which gave clues about the potential roles of these lncRNAs in the process of gastric cancer progression. | 25769450 | |
| EL1431 | UCA1 | gastric cancer | qPCR etc. | cancerous gastric tissue, blood (serum) | up-regulated | expression | A three-lncRNA signature, including CUDR, LSINCT-5 and PTENP1, was identified that may be potential diagnostic marker for GC. Moreover, a risk model for the serum three-lncRNA signature demonstrated that healthy samples can be distinguished from early GC samples. Three-lncRNA signature in serum was identified as diagnostic marker for GC. | 25694351 | Lnc2Cancer |
| EL1431 | UCA1 | gastric cancer | qPCR etc. | gastric cancer tissue, cell lines (SGC-7901, BGC-823, MKN-28) | up-regulated | N/A | UCA1 expression was remarkably increased in gastric cancer tissues and cell lines compared with that in the normal control; high UCA1 expression correlated with worse differentiation, tumor size, invasion depth and TNM stage in gastric cancer; increased UCA1 expression contributed to poor overall survival and disease-free survival of patients. | 25903045 | LncRNADisease Lnc2Cancer |
| EL1431 | UCA1 | gastric cancer | quantitative real-time PCR | N/A | up-regulated | N/A | Silence of UCA1 could significantly inhibit the cell proliferation of gastric cancer | 27056384 | |
| EL1450 | VTRNA2-1 | gastric cancer | RNA-seq, qPCR etc. | gastric cancer tissue, gastric cell lines | down-regulated | N/A | Our real-time RT-PCR data (Fig 1A) indicated that the expression level of nc886 was lower in a subpopulation of tumor tissues than in normal tissues. nc886 inhibits cell proliferation when ectopically expressed in gastric cancer cells. | 25003254 | Lnc2Cancer |
| EL1456 | WT1-AS | gastric cancer | qPCR etc. | gastric cancer tissue, cell lines (SGC7901, BGC823, MKN45, MKN28, NCI-N87, AGS, HS-746T, GES-1) | down-regulated | expression | We found that WT1-AS expression was significantly down-regulated in tumor tissues compared to matched adjacent non-tumor tissues. The WT1-AS expression level was also associated with tumor size and the clinicopathological stage. Cell proliferation, migration, and invasion were inhibited, and the proportion of G0/G1 cells increased when WT1-AS was ectopically-expressed in gastric cancer cells. Furthermore, ectopic expression of WT1-AS was demonstrated to inhibit tumor growth and metastasis in vivo. Finally, we found that WT1-AS overexpression could decrease ERK protein phosphorylation. | 26449525 | Lnc2Cancer |
| EL1500 | XLOC_010235 | gastric cancer | microarray, qPCR etc. | gastric cancer tissue | up-regulated | interaction | The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. | 26045391 | Lnc2Cancer |
| EL1524 | ZMAT1 | gastric cancer | qPCR etc. | gastric cancer tissue | down-regulated | expression | We found for the first time that the lncRNA ZMAT1 transcript variant 2 is downregulated in gastric cancer tissues compared with adjacent normal tissues (P<0.001). The expression of ZMAT1 transcript variant 2 was inversely correlated with lymph node metastasis (P<0.05), depth of tumor invasion and tumor node metastasis stage (P<0.05). Univariate and multivariate analyses showed that ZMAT1 transcript variant 2 expression was an independent predictor for overall survival (P<0.05) | 26191264 | Lnc2Cancer |