Related LncRNAs |
ID |
lncRNA Name |
Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
EL0227 |
BANCR |
gastric adenocarcinoma |
qPCR, Western blot, knockdown, MTT assay etc. |
gastric adenocarcinoma tissue, cell lines (BGC823, SGC7901) |
up-regulated |
interaction |
BANCR expression was significantly up-regulated in gastric tumor tissues and gastric cell lines. Down-regulation of BANCR inhibited gastric cancer cell growth and promoted cell apoptosis, and it also contributed to a significant decrease of NF-B1 (P50/105) expression and 3'UTR of NF-B1 activity. Overexpression of NF-B1 reversed the effect of BANCR on cancer cell growth and apoptosis. MiroRNA-9 (miR-9) targeted NF-B1, and miR-9 inhibitor also reversed the effects of BANCR on gastric cancer cell growth and apoptosis. |
26248136 |
Lnc2Cancer
|
EL0578 |
HOTAIR |
gastric adenocarcinoma |
qPCR etc. |
gastric adenocarcinoma tissue |
up-regulated |
N/A |
Here, we found aberrant up-regulation of HOTAIR in gastric adenocarcinoma samples compared with normal adjacent gastric epithelium tissues. Besides, we found that the aberrant expression of HOTAIR was associated with TNM staging and lymph node metastasis of gastric tumors. Here, a potential cooperative expression between HOTAIR SUZ12 genes in gastric adenocarcinoma tissues is deduced. This result suggests a role for HOTAIR long noncoding RNA in gastric cancer progression. |
23888369 |
Lnc2Cancer
|
EL0578 |
HOTAIR |
gastric adenocarcinoma |
qPCR etc. |
gastric cancer tissue |
up-regulated |
expression |
HOTAIR was significantly upregulated in GA tissues, especially in more advanced cases. High HOTAIR expression was an independent poor prognostic factor for patients with advanced GA. Further stratification analyses revealed that the association between HOTAIR expression and survival in patients with advanced GA remained significant in the subgroup of patients with TNM stages IIIA and IIIB, poorly differentiated, and smaller tumors. |
26328013 |
Lnc2Cancer
|
EL0973 |
NEAT1 |
gastric adenocarcinoma |
GAC tissues and matched adjacent normal qRT-PCR |
gastric adenocarcinomas (GACs) |
up-regulated |
N/A |
Expression of NEAT1 lncRNA was enhanced in GACs and influence GAC progression by promoting tumor growth |
26911892 |
|
|