| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0354 | DNM3OS | epithelial ovarian cancer | qPCR etc. | cell lines (type I, type II etc.) | up-regulated | locus | pri-miR-199a2 within the human Dnm3os gene. The regulation of MIR199A2/214 expression may be used as a potential therapeutic approach in EOC (epithelial ovarian cancer) patients. | 20400975 | LncRNADisease Lnc2Cancer |
| EL0577 | HOST2 | epithelial ovarian cancer | qPCR, Western blot etc. | ovarian cancer tissue, cells lines (OVCAR3) | up-regulated | N/A | EOC-specific lncRNA-HOST2, which acts as a miRNA sponge, sequesters let-7b to maintain the expression of oncogenes and further maintains EOC biological functions. | 25292198 | LncRNADisease Lnc2Cancer |
| EL0861 | MEG3 | epithelial ovarian cancer | qPCR, MSP, Western blot, Luciferase reporter assay etc. | epithelial ovarian cancer tissue, cell lines (OVCAR3, SKOV3, HP8910, ES-2) | down-regulated | N/A | In contrast to normal ovarian tissues, the expression of MEG3 was absent or decreased in most EOC tissues as well as in human EOC cell lines, and the promoter of the MEG3 gene was highly methylated in both cancer tissues and cell lines. In addition, ectopic expression of MEG3 suppressed the proliferation and growth of OVCAR3 cells and promoted apoptosis. Finally, MEG3 activated p53 in OVCAR3 cells. | 24859196 | Lnc2Cancer |
| EL1266 | TC0100223 | epithelial ovarian cancer | microarray, qPCR etc. | epithelial ovarian cancer tissue, cell lines (SKOV3 etc.) | down-regulated | expression | Notably, three candidates (TC0100223, TC0101686 and TC0101441) were aberrantly expressed in ERα-positive compared to ERα-negative EOC tissues, showing correlations with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade. | 24481591 | LncRNADisease Lnc2Cancer |
| EL1267 | TC0101441 | epithelial ovarian cancer | microarray, qPCR etc. | epithelial ovarian cancer tissue, cell lines (SKOV3 etc.) | up-regulated | expression | Notably, three candidates (TC0100223, TC0101686 and TC0101441) were aberrantly expressed in ERα-positive compared to ERα-negative EOC tissues, showing correlations with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade. | 24481591 | LncRNADisease Lnc2Cancer |
| EL1267 | TC0101441 | epithelial ovarian cancer | microarray, qPCR, Western blot, knockdown etc. | epithelial ovarian cancer tissue, cell lines (SKOV3, A2780, PEO1 etc.) | up-regulated | N/A | The results showed that ERa-positive tissues had higher expression of TC0101441 and lower expression TC0101686. Low-expression of TC0101686 was significantly related to ERa-positive EOC tissues with advanced FIGO stage ( P< 0.05), while high-expression of TC0101441 was closely correlated with advanced FIGO stage, high histological grade and lymph node metastasis (P<0.01). | 24380700 | Lnc2Cancer |
| EL1268 | TC0101686 | epithelial ovarian cancer | microarray, qPCR etc. | epithelial ovarian cancer tissue, cell lines (SKOV3 etc.) | down-regulated | expression | Notably, three candidates (TC0100223, TC0101686 and TC0101441) were aberrantly expressed in ERα-positive compared to ERα-negative EOC tissues, showing correlations with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade. | 24481591 | LncRNADisease Lnc2Cancer |
| EL1268 | TC0101686 | epithelial ovarian cancer | microarray, qPCR, Western blot, knockdown etc. | epithelial ovarian cancer tissue, cell lines (SKOV3, A2780, PEO1 etc.) | down-regulated | N/A | The results showed that ERa-positive tissues had higher expression of TC0101441 and lower expression TC0101686. Low-expression of TC0101686 was significantly related to ERa-positive EOC tissues with advanced FIGO stage ( P< 0.05), while high-expression of TC0101441 was closely correlated with advanced FIGO stage, high histological grade and lymph node metastasis (P<0.01). | 24380700 | Lnc2Cancer |
| EL1431 | UCA1 | epithelial ovarian cancer | N/A | EOC tissues and cells | up-regulated | N/A | upregulated in EOC tissues and cells, but also correlated with status of lymph; an endogenous sponge | 26867765 | |