Related LncRNAs
ID lncRNA Name Disease Method Sample Expression pattern Dysfunction type Description PMID Source
EL0242 BGLT3 chronic myeloid leukemia microarray, qPCR, Western blot etc. cell lines (K562) up-regulated N/A We observed that lncRNA-BGL3 was highly induced in response to disruption of Bcr-Abl expression or by inhibiting Bcr-Abl kinase activity in K562 cells and leukemic cells derived from CML patients. Ectopic expression of lncRNA-BGL3 sensitized leukemic cells to undergo apoptosis and inhibited Bcr-Abl-induced tumorigenesis. 24837367 Lnc2Cancer
EL0556 H19 chronic myeloid leukemia qPCR, Western blot etc. cell lines (K562) up-regulated N/A We observed that H19 was highly expressed in Bcr-Abl-expressing primary CML cells derived from 4 patients, and imatinib treatment greatly decreased the expression of H19 in these cells but not in normal control cells. Loss of either Bcr-Abl expression or Abl kinase activity caused decrease of c-Myc levels with simultaneously reduced levels of H19. Furthermore, we demonstrated that depletion of c-Myc alone in K562 cells significantly decreased the level of H19, suggesting that H19 is expressed in a c-Myc dependent manner in K562 leukemic cells. 24685695 Lnc2Cancer
EL0861 MEG3 chronic myeloid leukemia qPCR, ISH etc. blood down-regulated expression MEG3 expression is lost. 14602737 LncRNADisease Lnc2Cancer