Related LncRNAs | |||||||||
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ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
EL0242 | BGLT3 | chronic myeloid leukemia | microarray, qPCR, Western blot etc. | cell lines (K562) | up-regulated | N/A | We observed that lncRNA-BGL3 was highly induced in response to disruption of Bcr-Abl expression or by inhibiting Bcr-Abl kinase activity in K562 cells and leukemic cells derived from CML patients. Ectopic expression of lncRNA-BGL3 sensitized leukemic cells to undergo apoptosis and inhibited Bcr-Abl-induced tumorigenesis. | 24837367 | Lnc2Cancer |
EL0556 | H19 | chronic myeloid leukemia | qPCR, Western blot etc. | cell lines (K562) | up-regulated | N/A | We observed that H19 was highly expressed in Bcr-Abl-expressing primary CML cells derived from 4 patients, and imatinib treatment greatly decreased the expression of H19 in these cells but not in normal control cells. Loss of either Bcr-Abl expression or Abl kinase activity caused decrease of c-Myc levels with simultaneously reduced levels of H19. Furthermore, we demonstrated that depletion of c-Myc alone in K562 cells significantly decreased the level of H19, suggesting that H19 is expressed in a c-Myc dependent manner in K562 leukemic cells. | 24685695 | Lnc2Cancer |
EL0861 | MEG3 | chronic myeloid leukemia | qPCR, ISH etc. | blood | down-regulated | expression | MEG3 expression is lost. | 14602737 | LncRNADisease Lnc2Cancer |