| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0296 | CHRF | cardiac hypertrophy | N/A | N/A | N/A | regulation | The Long Noncoding RNA CHRF Regulates Cardiac Hypertrophy by Targeting miR-489. | 24557880 | LncRNADisease |
| EL0556 | H19 | cardiac hypertrophy | N/A | normal and diseased hearts | up-regulated | N/A | overexpression of H19 reduced cell size both at baseline and in response to PE; knockdown of H19 induced cardiomyocyte hypertroph | 27084844 | |
| EL1120 | RN7SK | cardiac hypertrophy | N/A | N/A | N/A | Interaction | Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex. Active and inactive forms of P-TEFb are kept in a functional and dynamic equilibrium tightly linked to the transcriptional requirement of the cell. Importantly, cardiac hypertrophy and development of various types of human malignancies have been associated with increased P-TEFb activity, consequence of a disruption of this regulatory equilibrium. | 22377309 | LncRNADisease |