Related LncRNAs |
ID |
lncRNA Name |
Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
EL0296 |
CHRF |
cardiac hypertrophy |
N/A |
N/A |
N/A |
regulation |
The Long Noncoding RNA CHRF Regulates Cardiac Hypertrophy by Targeting miR-489. |
24557880 |
LncRNADisease
|
EL0556 |
H19 |
cardiac hypertrophy |
N/A |
normal and diseased hearts |
up-regulated |
N/A |
overexpression of H19 reduced cell size both at baseline and in response to PE; knockdown of H19 induced cardiomyocyte hypertroph |
27084844 |
|
EL1120 |
RN7SK |
cardiac hypertrophy |
N/A |
N/A |
N/A |
Interaction |
Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex. Active and inactive forms of P-TEFb are kept in a functional and dynamic equilibrium tightly linked to the transcriptional requirement of the cell. Importantly, cardiac hypertrophy and development of various types of human malignancies have been associated with increased P-TEFb activity, consequence of a disruption of this regulatory equilibrium. |
22377309 |
LncRNADisease
|
|