Related LncRNAs
ID lncRNA Name Disease Method Sample Expression pattern Dysfunction type Description PMID Source
EL0580 HOTAIRM1 acute promyelocytic leukemia qPCR, knockdown etc. cell lines (NB4, HEK293) up-regulated N/A HOTAIRM1 is Highly expressed and provides a regulatory link in myeloid maturation by modulating integrin-controlled cell cycle progression at the gene expression level. 24824789 Lnc2Cancer
EL0973 NEAT1 acute promyelocytic leukemia qPCR, Western blot etc. blood, cell lines (NB4, NB4-R2, U937-PR9) down-regulated expression We found that NEAT1 is significantly repressed in de novo APL samples compared with those of healthy donors. We further provide evidence that NEAT1 expression was repressed by PML-RAR抅 Furthermore, significant NEAT1 upregulation was observed during all-trans retinoic acid (ATRA)-induced NB4 cell differentiation. 25245097 Lnc2Cancer
EL1102 PVT1 acute promyelocytic leukemia knockdown peripheral blood cells from 28 patients with de novo APL up-regulated interaction Significantly lower MYC and PVT1 expression was observed during all-trans retinoic acid (ATRA)-induced differentiation and cell cycle arrest in the APL cell line. MYC knockdown in NB4 cells led to PVT1 downregulation. Moreover, PVT1 knockdown by RNA interference led to suppression of the MYC protein level, and cell proliferation was inhibited. 26544536