Related LncRNAs |
ID |
lncRNA Name |
Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
EL0564 |
HCP5 |
AIDS |
N/A |
N/A |
N/A |
mutation |
HCP5 genotyping could serve as a simple screening tool for ABC-HSR. |
18684101 |
LncRNADisease
|
EL0564 |
HCP5 |
AIDS |
N/A |
N/A |
N/A |
mutation |
A polymorphism (rs2395029, G824T) in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro. |
19935381 |
LncRNADisease
|
EL0564 |
HCP5 |
AIDS |
N/A |
N/A |
N/A |
expression |
A total of 245 HIV patients were included in the study. A good correlation between HLA-B*5701 and HCP5 was observed (negative and positive predictive values of 100% and 93%, respectively). |
20534626 |
LncRNADisease
|
EL0573 |
HLA-AS1 |
AIDS |
N/A |
N/A |
N/A |
mutation |
HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles. |
18982067 |
LncRNADisease
|
EL0973 |
NEAT1 |
AIDS |
N/A |
N/A |
N/A |
expression |
We found NEAT-1 to be one of several lncRNAs whose expression is changed by HIV-1 infection, and we have characterized its role in HIV-1 replication. |
23362321 |
LncRNADisease
|
EL1013 |
NRON |
AIDS |
N/A |
N/A |
N/A |
N/A |
The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins. Its expression was significantly altered following HIV-1 infection. Its levels were reduced by the early viral accessory protein Nef and increased by the late protein Vpu. |
25728138 |
LncRNADisease
|
EL1120 |
RN7SK |
AIDS |
N/A |
N/A |
N/A |
Interaction |
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. |
20471949 |
LncRNADisease
|
EL1120 |
RN7SK |
AIDS |
N/A |
N/A |
N/A |
Interaction |
Tat efficiently replaces HEXIM1 on the 7SK snRNA in vivo and therefore, it promotes the disassembly of the 7SK/HEXIM/P-TEFb negative transcriptional regulatory snRNP to augment the nuclear level of active P-TEFb. The human 7SK snRNA carries a TAR RNA-like Tat-binding element that is essential for the normal transcriptional regulatory function of 7SK questions the viability of HIV therapeutic approaches based on small drugs blocking the Tat-binding site of HIV TAR. |
20976203 |
LncRNADisease
|
EL1120 |
RN7SK |
AIDS |
N/A |
N/A |
N/A |
Interaction |
The 7SK-HMGA1 interaction not only adds an essential facet to the comprehension of transcriptional plasticity at the coupling of initiation and elongation, but also might provide a molecular link between HIV reprogramming of cellular gene expression-associated oncogenesis. |
21087998 |
LncRNADisease
|
EL1120 |
RN7SK |
AIDS |
N/A |
N/A |
N/A |
expression |
Stable expression of cdNIPP1 increased CDK9 phosphorylation on Thr(186) and the association of CDK9 with 7SK RNA. The stable expression of cdNIPP1 disrupted the interaction of Tat and PP1 and inhibited HIV-1 transcription. Expression of cdNIPP1 as a part of the HIV-1 genome inhibited HIV-1 replication. |
21098020 |
LncRNADisease
|
EL1120 |
RN7SK |
AIDS |
N/A |
N/A |
N/A |
Interaction |
The HIV-1 Tat protein also releases P-TEFb from the 7SK/HEXIM complex during viral infection to promote viral transcription and replication. |
22377309 |
LncRNADisease
|
EL1121 |
RN7SL1 |
AIDS |
N/A |
N/A |
N/A |
Interaction |
7SL RNA, but not the 54-kd signal recognition particle protein, is an abundant component of both infectious HIV-1 and minimal virus-like particles. |
16489186 |
LncRNADisease
|
EL1121 |
RN7SL1 |
AIDS |
N/A |
N/A |
N/A |
N/A |
7SL RNA binding is a conserved feature of human anti-HIV-1 cytidine deaminases. |
20926562 |
LncRNADisease
|
|